Thyroid autoimmunity and dysfunction in multiple sclerosis patients during long-term treatment with interferon beta or glatiramer acetate: an Italian multicenter study

被引：17

作者：

Frisullo, Giovanni ^{[1
]}

Calabrese, Massimiliano ^{[2
]}

Tortorella, Carla ^{[3
]}

Paolicelli, Damiano ^{[3
]}

Ragonese, Paolo ^{[4
]}

Annovazzi, Pietro ^{[5
]}

Radaelli, Marta ^{[6
]}

Malucchi, Simona ^{[7
]}

Gallo, Antonio ^{[8
]}

Tomassini, Valentina ^{[9
]}

Nociti, Viviana ^{[1
,10
]}

D'Onghia, Mariangela ^{[3
]}

Lo Re, Vincenzina ^{[4
]}

Rodegher, Mariemma ^{[6
]}

Solaro, Claudio ^{[11
]}

Gasperini, Claudio ^{[12
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Neurosci, Milan, Italy

[2] Univ Verona, Dept Neurol & Movement Sci, I-37100 Verona, Italy

[3] Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70121 Bari, Italy

[4] Univ Palermo, Dept Expt Biomed & Clin Neurosci, I-90133 Palermo, Italy

[5] AO St Antonio Abate Gallarate VA, Ctr Studi SM, Gallarate Varese, Italy

[6] Hosp San Raffaele, Dept Neurol, I-20132 Milan, Italy

[7] AOU San Luigi Gonzaga, Ctr Riferimento Regionale Sclerosi Multipla Neuro, Orbassano, Italy

[8] Univ Naples 2, Dept Med Surg Neurol Metab & Aging Sci, Naples, Italy

[9] Cardiff Univ, Inst Psychol Med & Clin Neurosci, Sch Med, Univ Wales Hosp, Cardiff CF10 3AX, S Glam, Wales

[10] Don Carlo Gnocchi Fdn, Rome, Italy

[11] Azienda Sanit Locale 3, Neurol Unit, Genoa, Italy

[12] San Camillo Forlanini Hosp, Rome, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 09期

关键词：

Adverse effects; autoimmunity; glatiramer acetate; interferon beta; multiple sclerosis; thyroid; AUTOANTIBODIES; THERAPY; DISEASE;

D O I：

10.1177/1352458514521311

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Few long-term follow-up data are available on thyroid dysfunction (TD) in multiple sclerosis (MS) patients treated with glatiramer acetate (GA) or with interferon-beta (IFNb). In a cohort of 787 relapsing-remitting MS (RRMS) patients whom were followed up for 8 years, we observed an increased prevalence of TD and thyroid autoimmunity (TA) within the first year of IFNb treatment, regardless of the dose or frequency of administration, while no change was observed with GA treatment. The increased prevalence of TD and TA within the first year of IFNb treatment suggested the need for close monitoring of thyroid function and autoimmunity, though only during the first year of IFNb treatment.

引用

页码：1265 / 1268

页数：4

共 50 条

[31] Early stage and long term treatment of multiple sclerosis with interferon-beta [J].

Applebee, Angela ;

Panitch, Hillel .

BIOLOGICS-TARGETS & THERAPY, 2009, 3 :257-271

[32] Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis [J].

Croze, E. ;

Yamaguchi, K. D. ;

Knappertz, V. ;

Reder, A. T. ;

Salamon, H. .

PHARMACOGENOMICS JOURNAL, 2013, 13 (05) :443-451

[33] Glatiramer acetate versus interferon beta-1a for subcutaneous administration: Comparison of outcomes among multiple sclerosis patients [J].

Jane Castelli-Haley ;

Merry-Kay A. Oleen-Burkey ;

Maureen J. Lage ;

Kenneth P. Johnson .

Advances in Therapy, 2008, 25 :658-673

[34] Glatiramer acetate versus interferon beta-1a for subcutaneous administration: Comparison of outcomes among multiple sclerosis patients [J].

Castelli-Haley, Jane ;

Oleen-Burkey, Merry-Kay A. ;

Lage, Maureen J. ;

Johnson, Kenneth P. .

ADVANCES IN THERAPY, 2008, 25 (07) :658-673

[35] Thyroid autoimmunity disorders during interferon β-1b treatment in patients with multiple sclerosis:: review and case report [J].

Lange-Asschenfeldt, C ;

Boor, S ;

Kahaly, GJ ;

Thömke, F .

NERVENARZT, 2004, 75 (06) :589-+

[36] Spasticity improvement in patients with relapsing-remitting multiple sclerosis switching from interferon-β to glatiramer acetate: The Escala Study [J].

Meca-Lallana, J. E. ;

Balseiro, J. J. ;

Lacruz, F. ;

Guijarro, C. ;

Sanchez, O. ;

Cano, A. ;

Costa-Frossard, L. ;

Hernandez-Clares, R. ;

Sanchez-de la Rosa, R. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 315 (1-2) :123-128

[37] Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: the Italian experience [J].

Angelo Ghezzi ;

Maria Pia Amato ;

Pietro Annovazzi ;

Marco Capobianco ;

Paolo Gallo ;

Loredana La Mantia ;

Maria Giovanna Marrosu ;

Vittorio Martinelli ;

Nicoletta Milani ;

Lucia Moiola ;

Francesco Patti ;

Carlo Pozzilli ;

Maria Trojano ;

Mauro Zaffaroni ;

Giancarlo Comi .

Neurological Sciences, 2009, 30 :193-199

[38] Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: the Italian experience [J].

Ghezzi, Angelo ;

Amato, Maria Pia ;

Annovazzi, Pietro ;

Capobianco, Marco ;

Gallo, Paolo ;

La Mantia, Loredana ;

Marrosu, Maria Giovanna ;

Martinelli, Vittorio ;

Milani, Nicoletta ;

Moiola, Lucia ;

Patti, Francesco ;

Pozzilli, Carlo ;

Trojano, Maria ;

Zaffaroni, Mauro ;

Comi, Giancarlo .

NEUROLOGICAL SCIENCES, 2009, 30 (03) :193-199

[39] The norepinephrine level is decreased in the lymphocytes of long-term interferon-beta-treated multiple sclerosis patients [J].

Rajda, C ;

Bencsik, K ;

Füvesi, J ;

Seres, E ;

Vécsei, L ;

Bergquist, J .

MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (03) :265-270

[40] Thyroid Dysfunction and Long-term Outcome during and after Interferon-alpha Therapy in Patients with Chronic Hepatitis C [J].

Themistoklis, Vasiliadis ;

Panagiotis, Anagnostis ;

Georgios, Nalmpantidis ;

Konstantinos, Soufleris ;

Kaliopi, Patsiaoura ;

Nikolaos, Grammatikos ;

Eleni, Orfanou-Koumerkeridou ;

Konstantinos, Kargiotis ;

Aristidis, Slavakis ;

Aristidis, Deliyiannidis ;

Nikolaos, Eugenidis .

ANNALS ACADEMY OF MEDICINE SINGAPORE, 2011, 40 (09) :394-400

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