Thyroid autoimmunity and dysfunction in multiple sclerosis patients during long-term treatment with interferon beta or glatiramer acetate: an Italian multicenter study

被引：17

作者：

Frisullo, Giovanni ^{[1
]}

Calabrese, Massimiliano ^{[2
]}

Tortorella, Carla ^{[3
]}

Paolicelli, Damiano ^{[3
]}

Ragonese, Paolo ^{[4
]}

Annovazzi, Pietro ^{[5
]}

Radaelli, Marta ^{[6
]}

Malucchi, Simona ^{[7
]}

Gallo, Antonio ^{[8
]}

Tomassini, Valentina ^{[9
]}

Nociti, Viviana ^{[1
,10
]}

D'Onghia, Mariangela ^{[3
]}

Lo Re, Vincenzina ^{[4
]}

Rodegher, Mariemma ^{[6
]}

Solaro, Claudio ^{[11
]}

Gasperini, Claudio ^{[12
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Neurosci, Milan, Italy

[2] Univ Verona, Dept Neurol & Movement Sci, I-37100 Verona, Italy

[3] Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70121 Bari, Italy

[4] Univ Palermo, Dept Expt Biomed & Clin Neurosci, I-90133 Palermo, Italy

[5] AO St Antonio Abate Gallarate VA, Ctr Studi SM, Gallarate Varese, Italy

[6] Hosp San Raffaele, Dept Neurol, I-20132 Milan, Italy

[7] AOU San Luigi Gonzaga, Ctr Riferimento Regionale Sclerosi Multipla Neuro, Orbassano, Italy

[8] Univ Naples 2, Dept Med Surg Neurol Metab & Aging Sci, Naples, Italy

[9] Cardiff Univ, Inst Psychol Med & Clin Neurosci, Sch Med, Univ Wales Hosp, Cardiff CF10 3AX, S Glam, Wales

[10] Don Carlo Gnocchi Fdn, Rome, Italy

[11] Azienda Sanit Locale 3, Neurol Unit, Genoa, Italy

[12] San Camillo Forlanini Hosp, Rome, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 09期

关键词：

Adverse effects; autoimmunity; glatiramer acetate; interferon beta; multiple sclerosis; thyroid; AUTOANTIBODIES; THERAPY; DISEASE;

D O I：

10.1177/1352458514521311

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Few long-term follow-up data are available on thyroid dysfunction (TD) in multiple sclerosis (MS) patients treated with glatiramer acetate (GA) or with interferon-beta (IFNb). In a cohort of 787 relapsing-remitting MS (RRMS) patients whom were followed up for 8 years, we observed an increased prevalence of TD and thyroid autoimmunity (TA) within the first year of IFNb treatment, regardless of the dose or frequency of administration, while no change was observed with GA treatment. The increased prevalence of TD and TA within the first year of IFNb treatment suggested the need for close monitoring of thyroid function and autoimmunity, though only during the first year of IFNb treatment.

引用

页码：1265 / 1268

页数：4

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