Activation-free one-pot alkynylation-cyclization synthesis of 2-substituted 4-azaindoles and indoles

被引：5
|
作者：
Lessing, Timo [1 ]
Mueller, Thomas J. J. [1 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Lehrstuhl Organ Chem, Inst Organ Chem & Makromol Chem, 1 Univ Str, D-40225 Dusseldorf, Germany
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 03期
关键词：
4-azaindoles; heterocycles; indoles; alkynylation; cyclization; one-pot reaction; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; INHIBITORS; FUNCTIONALIZATION; DERIVATIVES; DISCOVERY; DESIGN; OPTIMIZATION; HETEROCYCLES; KINASES;
D O I：
10.1007/s10593-018-2269-z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Substituted 4-azaindoles and indoles are rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation-cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.
引用
收藏
页码：334 / 338
页数：5
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