Association of Sarcopenia with and Efficacy of Anti-PD-1/PD-L1 Therapy in Non-Small-Cell Lung Cancer

被引：85

作者：

Nishioka, Naoya ^{[1
]}

Uchino, Junji ^{[1
]}

Hirai, Soichi ^{[1
]}

Katayama, Yuki ^{[1
]}

Yoshimura, Akihiro ^{[1
]}

Okura, Naoko ^{[1
]}

Tanimura, Keiko ^{[1
]}

Harita, Sachi ^{[1
]}

Imabayashi, Tatsuya ^{[1
]}

Chihara, Yusuke ^{[1
]}

Tamiya, Nobuyo ^{[1
]}

Kaneko, Yoshiko ^{[1
]}

Yamada, Tadaaki ^{[1
]}

Takayama, Koichi ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pulm Med, Kyoto 6028566, Japan

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 04期

关键词：

sarcopenia; non-small cell lung cancer; psoas major muscle area; red blood cell distribution width; TO-LYMPHOCYTE RATIO; DISTRIBUTION WIDTH; SUPPRESSOR-CELLS; SKELETAL-MUSCLE; CACHEXIA; OBESITY; DEFINITION; NIVOLUMAB; SURVIVAL; OUTCOMES;

D O I：

10.3390/jcm8040450

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Secondary sarcopenia is defined as a decrease in muscle mass due to disease or malnutrition. Several studies have reported that secondary sarcopenia is an indicator of postoperative recurrence. We hypothesized that there is a correlation between the effect of immune checkpoint inhibitors (ICIs) and sarcopenia. We retrospectively analyzed 38 patients with advanced non-small cell lung cancer (NSCLC) who were treated with ICIs between February 2016 and April 2018. Patients were divided into two groups according to the change rate of the psoas major muscle area (PMMA) at the L2-L3 position and investigated the correlation between the change rate of the PMMA and the efficacy of ICIs was investigated. The objective response and disease control rates were lower in patients with sarcopenia than in those without sarcopenia. Patients with sarcopenia exhibited a significantly shorter median progression-free survival (PFS) than non-sarcopenia patients. Moreover, focusing on good Eastern Cooperative Oncology Group performance status patients, sarcopenia patients showed a shorter PFS than non-sarcopenia patients. Patients with sarcopenia are associated with poor outcomes for immunotherapy among those with advanced NSCLC, based on retrospective analysis. Further research is needed to validate the clinical biomarkers involved in ICI responders.

引用

页数：12

共 32 条

[1] Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer [J].

Almand, B ;

Clark, JI ;

Nikitina, E ;

van Beynen, J ;

English, NR ;

Knight, SC ;

Carbone, DP ;

Gabrilovich, DI .

JOURNAL OF IMMUNOLOGY, 2001, 166 (01) :678-689

[2] Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer [J].

Bagley, Stephen J. ;

Kothari, Shawn ;

Aggarwal, Charu ;

Bauml, Joshua M. ;

Alley, Evan W. ;

Evans, Tracey L. ;

Kosteva, John A. ;

Ciunci, Christine A. ;

Gabriel, Peter E. ;

Thompson, Jeffrey C. ;

Stonehouse-Lee, Susan ;

Sherry, Victoria E. ;

Gilbert, Elizabeth ;

Eaby-Sandy, Beth ;

Mutale, Faith ;

DiLullo, Gloria ;

Cohen, Roger B. ;

Vachani, Anil ;

Langer, Corey J. .

LUNG CANCER, 2017, 106 :1-7

[3] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[4] Sarcopenia: European consensus on definition and diagnosis [J].

Cruz-Jentoft, Alfonso J. ;

Baeyens, Jean Pierre ;

Bauer, Juergen M. ;

Boirie, Yves ;

Cederholm, Tommy ;

Landi, Francesco ;

Martin, Finbarr C. ;

Michel, Jean-Pierre ;

Rolland, Yves ;

Schneider, Stephane M. ;

Topinkova, Eva ;

Vandewoude, Maurits ;

Zamboni, Mauro .

AGE AND AGEING, 2010, 39 (04) :412-423

[5] Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab [J].

Diem, Stefan ;

Schmid, Sabine ;

Krapf, Mirjam ;

Flatz, Lukas ;

Born, Diana ;

Jochum, Wolfram ;

Templeton, Arnoud J. ;

Fruh, Martin .

LUNG CANCER, 2017, 111 :176-181

[6] Quantitative analysis of skeletal muscle by computed tomography imaging-State of the art [J].

Engelke, Klaus ;

Museyko, Oleg ;

Wang, Ling ;

Laredo, Jean-Denis .

JOURNAL OF ORTHOPAEDIC TRANSLATION, 2018, 15 :91-103

[7] Cachexia: A new definition [J].

Evans, William J. ;

Morley, John E. ;

Argiles, Josep ;

Bales, Connie ;

Baracos, Vickie ;

Guttridge, Denis ;

Jatoi, Aminah ;

Kalantar-Zadeh, Kamyar ;

Lochs, Herbert ;

Mantovani, Giovanni ;

Marks, Daniel ;

Mitch, William E. ;

Muscaritoli, Maurizio ;

Najand, Armine ;

Ponikowski, Piotr ;

Rossi Fanelli, Filippo ;

Schambelan, Morrie ;

Schols, Annemie ;

Schuster, Michael ;

Thomas, David ;

Wolfe, Robert ;

Anker, Stefan D. ;

Boyce, Amanda ;

Nuckolls, Glen .

CLINICAL NUTRITION, 2008, 27 (06) :793-799

[8] Definition and classification of cancer cachexia: an international consensus [J].

Fearon, Kenneth ;

Strasser, Florian ;

Anker, Stefan D. ;

Bosaeus, Ingvar ;

Bruera, Eduardo ;

Fainsinger, Robin L. ;

Jatoi, Aminah ;

Loprinzi, Charles ;

MacDonald, Neil ;

Mantovani, Giovanni ;

Davis, Mellar ;

Muscaritoli, Maurizio ;

Ottery, Faith ;

Radbruch, Lukas ;

Ravasco, Paula ;

Walsh, Declan ;

Wilcock, Andrew ;

Kaasa, Stein ;

Baracos, Vickie E. .

LANCET ONCOLOGY, 2011, 12 (05) :489-495

[9] Red cell distribution width as a novel prognostic marker in heart failure - Data from the CHARM program and the Duke Databank [J].

Felker, G. Michael ;

Allen, Larry A. ;

Pocock, Stuart J. ;

Shaw, Linda K. ;

McMurray, John J. V. ;

Pfeffer, Marc A. ;

Swedberg, Karl ;

Wang, Duolao ;

Yusuf, Salim ;

Michelson, Eric L. ;

Granger, Christopher B. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (01) :40-47

[10] Connecting the Metabolic and Immune Responses to Cancer [J].

Flint, Thomas R. ;

Fearon, Douglas T. ;

Janowitz, Tobias .

TRENDS IN MOLECULAR MEDICINE, 2017, 23 (05) :451-464

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