A Small Molecule for Controlled Generation of Reactive Oxygen Species (ROS)

被引：36
作者：
Dharmaraja, Allimuthu T. [1 ]
Chakrapani, Harinath [1 ]
机构：
[1] Indian Inst Sci Educ & Res Pune, Pune 411008, Maharashtra, India
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 02期
关键词：
ESCHERICHIA-COLI; CELL-DEATH; SUPEROXIDE; NITROREDUCTASE; ANTIBIOTICS;
D O I：
10.1021/ol403300a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Due to the short half-life of reactive oxygen species (ROS) such as a superoxide radical, controlled and localized generation of ROS is challenging. Here, we report a rationally designed small-molecule 1c that generates ROS only when triggered by a bacterial enzyme. We provide evidence for 1c predictably enhancing the intracellular superoxide radical in a model bacterium. Spatiotemporal control over ROS generation offered by 1c should help better understand stress responses in bacteria to increased ROS.
引用
收藏
页码：398 / 401
页数：4
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