Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults

被引:14
作者
McIver, Theresa A. [1 ]
Bosma, Rachael L. [1 ]
Goegan, Sarah [2 ]
Sandre, Aislinn [2 ]
Klassen, Janell [2 ]
Chiarella, Julian [2 ]
Booij, Linda [2 ,3 ]
Craig, Wendy [2 ]
机构
[1] Queens Univ, Ctr Neurosci Studies, Botterell Hall,18 Stuart St, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Dept Psychol, Humphrey Hall,62 Arch St, Kingston, ON K7L 3N6, Canada
[3] Concordia Univ, Dept Psychol, 7141 Sherbrooke St West, Montreal, PQ H4B 1R6, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Peer victimization; fMRI; Functional connectivity; Social exclusion; EMOTION REGULATION; ANXIETY DISORDER; NEURAL BASES; AMYGDALA; METAANALYSIS; PAIN; REJECTION; CORTEX; BRAIN; FMRI;
D O I
10.1016/j.jad.2019.04.085
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Peer victimization is associated with increased risk for depression, as well as increased neural response to social exclusion in the anterior cingulate cortex (ACC) and the amygdala. Altered functional connectivity (FxC) of fronto-limbic circuitry is associated with risk for various affective disorders. The present study examined the relationship between fronto-limbic FxC during social exclusion, prior peer victimization experience and depressive symptoms. Methods: Three mutually exclusive groups were formed: peer victimized (with a history of peer victimization), defenders (history of defending peers), and controls (no prior peer victimization experience) (n = 15/group; M-age = 17.7 years). Functional Magnetic Resonance Imaging data were collected while participants completed the Cyberball paradigm (simulating the experience of social exclusion). FxC between the Medial Prefrontal Cortex (MPFC), ACC, right insula and left amygdala, was compared between groups and examined in relation to depressive symptoms. Results: Prior peer victimization experience was associated with differences in fronto-limbic FxC across social inclusion and exclusion. Defenders displayed distinct shifts in FxC across the transition from being included to excluded. Peer victimized individuals exhibited a unique pattern of amygdala-specific FxC during inclusive interaction with peers, and in the continuous FxC across inclusion and exclusion. FxC of the MPFC-amygdala across inclusion and exclusion moderated the relationship between peer victimization and depressive symptoms. Limitations: Small sample size and cross-sectional design limit interpretation of the findings. Conclusions: Peer victimized individuals who exhibit continuous positive FxC of the MPFC-left amygdala across inclusion and exclusion may be at greater risk for depressive symptoms.
引用
收藏
页码:366 / 375
页数:10
相关论文
共 50 条
[1]  
[Anonymous], 2014, BULLYING SURVEILLANC
[2]   Bullying victimization in youths and mental health problems: 'Much ado about nothing'? [J].
Arseneault, L. ;
Bowes, L. ;
Shakoor, S. .
PSYCHOLOGICAL MEDICINE, 2010, 40 (05) :717-729
[3]  
Beck A. T., 1996, Manual for the beck depression inventory-II, V1, P82, DOI [10.1007/978-94-007-0753-5_156, DOI 10.1007/978-94-007-0753-5_156]
[4]   Development of neural systems for processing social exclusion from childhood to adolescence [J].
Bolling, Danielle Z. ;
Pitskel, Naomi B. ;
Deen, Ben ;
Crowley, Michael J. ;
Mayes, Linda C. ;
Pelphrey, Kevin A. .
DEVELOPMENTAL SCIENCE, 2011, 14 (06) :1431-1444
[5]   Dissociable brain mechanisms for processing social exclusion and rule violation [J].
Bolling, Danielle Z. ;
Pitskel, Naomi B. ;
Deen, Ben ;
Crowley, Michael J. ;
McPartland, James C. ;
Mayes, Linda C. ;
Pelphrey, Kevin A. .
NEUROIMAGE, 2011, 54 (03) :2462-2471
[6]   The brain's default network - Anatomy, function, and relevance to disease [J].
Buckner, Randy L. ;
Andrews-Hanna, Jessica R. ;
Schacter, Daniel L. .
YEAR IN COGNITIVE NEUROSCIENCE 2008, 2008, 1124 :1-38
[7]   A Quantitative Meta-Analysis of Functional Imaging Studies of Social Rejection [J].
Cacioppo, Stephanie ;
Frum, Chris ;
Asp, Erik ;
Weiss, Robin M. ;
Lewis, James W. ;
Cacioppo, John T. .
SCIENTIFIC REPORTS, 2013, 3
[8]   Alexithymia is associated with blunted anterior cingulate response to social rejection: implications for daily rejection [J].
Chester, David S. ;
Pond, Richard S., Jr. ;
DeWall, C. Nathan .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2015, 10 (04) :517-522
[9]   The interactive effect of social pain and executive functioning on aggression: an fMRI experiment [J].
Chester, David S. ;
Eisenberger, Naomi I. ;
Pond, Richard S., Jr. ;
Richman, Stephanie B. ;
Bushman, Brad J. ;
DeWall, C. Nathan .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2014, 9 (05) :699-704
[10]   Do neural responses to rejection depend on attachment style? An fMRI study [J].
DeWall, C. Nathan ;
Masten, Carrie L. ;
Powell, Caitlin ;
Combs, David ;
Schurtz, David R. ;
Eisenberger, Naomi I. .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2012, 7 (02) :184-192