Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review

被引:66
作者
Van de Sande, Leen [1 ,2 ]
Cosyns, Sarah [1 ,2 ]
Willaert, Wouter [1 ,2 ]
Ceelen, Wim [1 ,2 ]
机构
[1] Univ Ghent, Dept Human Struct & Repair, Lab Expt Surg, Ghent, Belgium
[2] Univ Ghent, Canc Res Inst Ghent CRIG, Ghent, Belgium
关键词
Albumin; intraperitoneal delivery; peritoneal metastasis; chemotherapy; peritoneum; HUMAN SERUM-ALBUMIN; PACLITAXEL PLUS GEMCITABINE; SOLVENT-BASED PACLITAXEL; PERITONEAL CARCINOMATOSIS; NAB-PACLITAXEL; PANCREATIC-CANCER; AEROSOL CHEMOTHERAPY; METHOTREXATE-ALBUMIN; MESOTHELIAL CELLS; SPARC EXPRESSION;
D O I
10.1080/10717544.2019.1704945
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding sites, which are able to bind and transport numerous endogenous and exogenous compounds. The development of albumin-bound drugs is gaining increased importance in the targeted delivery of cancer therapy. Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal metastasis (PM). PM is characterized by the presence of widespread metastatic tumor nodules on the peritoneum, mostly originating from gastro-intestinal or gynaecological cancers. Albumin as a carrier for chemotherapy holds considerable promise for IP delivery in patients with PM. Data from recent (pre)clinical trials suggest that IP albumin-bound chemotherapy may result in superior efficacy in the treatment of PM compared to standard chemotherapy formulations. Here, we review the evidence on albumin-bound chemotherapy with a focus on IP administration and its efficacy in PM.
引用
收藏
页码:40 / 53
页数:14
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