Preventing and Treating Anthracycline Cardiotoxicity: New Insights

被引：122

作者：

Sawicki, Konrad Teodor ^{[1
]}

Sala, Valentina ^{[2
]}

Prever, Lorenzo ^{[2
]}

Hirsch, Emilio ^{[2
]}

Ardehali, Hossein ^{[1
]}

Ghigo, Alessandra ^{[2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc & Renal Res Inst, Div Cardiol, Chicago, IL 60611 USA

[2] Univ Torino, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 | 2021年 / 61卷

关键词：

anthracyclines; doxorubicin; cardiotoxicity; left ventricular dysfunction; heart failure; oxidative stress; DOXORUBICIN-INDUCED CARDIOTOXICITY; SECONDARY ALCOHOL METABOLITE; ACUTE LYMPHOBLASTIC-LEUKEMIA; GENOME-WIDE ASSOCIATION; BREAST-CANCER PATIENTS; OXIDATIVE STRESS; HEART-FAILURE; RISK-FACTORS; CARDIOMYOCYTE APOPTOSIS; GENETIC POLYMORPHISMS;

D O I：

10.1146/annurev-pharmtox-030620-104842

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Anthracyclines are the cornerstone of many chemotherapy regimens for a variety of cancers. Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite more than five decades of research, the biological mechanisms underlying anthracycline cardiotoxicity are not completely understood. In this review, we discuss the incidence, risk factors, types, and pathophysiology of anthracycline cardiotoxicity, as well as methods to prevent and treat this condition. We also summarize and discuss advances made in the last decade in the comprehension of the molecular mechanisms underlying the pathology.

引用

页码：309 / 332

页数：24

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