Mesenchymal Stem Cells: The Magic Cure for Intraventricular Hemorrhage?

被引：29

作者：

Park, Won Soon ^{[1
,2
,3
]}

Ahn, So Yoon ^{[1
,2
]}

Sung, Se In ^{[1
]}

Ahn, Jee-Yin ^{[4
]}

Chang, Yun Sil ^{[1
,2
,3
]}

机构：

[1] Sungkyunkwan Univ Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea

[2] Samsung Med Ctr, Stem Cell & Regenerat Med Inst, Seoul, South Korea

[3] Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea

[4] Sungkyunkwan Univ Sch Med, Dept Mol Cell Biol, Suwon, South Korea

来源：

CELL TRANSPLANTATION | 2017年 / 26卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Intraventricular hemorrhage (IVH); Premature infant; Hydrocephalus; Mesenchymal stem cells (MSCs); Cell transplantation; UMBILICAL-CORD BLOOD; POSTHEMORRHAGIC VENTRICULAR DILATION; NEONATAL BRAIN-INJURY; BIRTH-WEIGHT INFANTS; INDUCED LUNG INJURY; BONE-MARROW; GERMINAL MATRIX; ADIPOSE-TISSUE; STROMAL CELLS; INTRATRACHEAL TRANSPLANTATION;

D O I：

10.3727/096368916X694193

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Severe intraventricular hemorrhage (IVH) remains a major cause of mortality and long-term neurologic morbidities in premature infants, despite recent advances in neonatal intensive care medicine. Several preclinical studies have demonstrated the beneficial effects of mesenchymal stem cell (MSC) transplantation in attenuating brain injuries resulting from severe IVH. Because there currently exists no effective intervention for severe IVH, the therapeutic potential of MSC transplantation in this intractable and devastating disease is creating excitement in this field. This review summarizes recent progress in stem cell research for treating neonatal brain injury due to severe IVH, with a particular focus on preclinical data concerning important issues, such as mechanism of protective action and determining optimal source, route, timing, and dose of MSC transplantation, and on the translation of these preclinical study results to a clinical trial.

引用

页码：439 / 448

页数：10

共 94 条

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