Zn(ODf)2:: preparation and application in asymmetric alkynylation of aldehydes

被引：48

作者：

Chen, ZL ^{[1
]}

Xiong, WN ^{[1
]}

Jiang, B ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 18期

关键词：

D O I：

10.1039/b206868k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new Lewis acid, Zn(ODf)(2), was first prepared from commercially available 3,3,4,4-tetrafluoro[1,2] oxathietane 2,2-dioxide in four steps with 56% yields and also was applied to catalyze highly enantioselective alkynylation of aldehydes in the presence of ligand (1S,2S)-3-(tert-butyldimethylsilyloxyl)-2-N,N-dimethylamino-1-(p-nitrophenyl)propane-1-ol or ligand (-)-N-methylephedrine to afford the corresponding propargylic alcohols in high yields with up to 99% ee.

引用

页码：2098 / 2099

页数：2

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