Ion mobility spectrometry evaluation of cocaine occupational exposure in forensic laboratories

被引:16
作者
Armenta, Sergio [1 ]
de la Guardia, Miguel [1 ]
Alcala, Manel [2 ]
Blanco, Marcelo [2 ]
Perez-Alfonso, Clara [3 ]
Galipienso, Nieves [3 ]
机构
[1] Univ Valencia, Dept Analyt Chem, E-46100 Valencia, Spain
[2] Univ Autonoma Barcelona, Dept Chem, Fac Sci, E-08193 Barcelona, Spain
[3] Area Sanidad Valencia, Unidad Inspecc Farm, Valencia 46024, Spain
关键词
Cocaine; Air samples; Surface samples; Biological samples; Ion mobility spectrometry; Forensic laboratories; PREPARING TRAINING AIDS; CYCLOPHOSPHAMIDE; VALIDATION; URINE;
D O I
10.1016/j.talanta.2014.06.044
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An approach, based on ion mobility spectrometry (IMS) has been developed for the control of cocaine in air of the breathing zone of operators, in laboratory surfaces and in nasal mucus of employees to evaluate cocaine exposure in a forensic laboratory. The analytical methodology has been validated in terms of accuracy, precision and limits of detection and results obtained were statistically comparable with those obtained by liquid chromatography. Cocaine concentration in laboratory air increases from 100 +/- 35 ng m(-3) of a normal day to 10,000 ng m(-3) during the manipulation of cocaine seizures. The occupational exposure limit (OEL) for cocaine has not been established which difficult the evaluation of the health effects of continuous exposition to very small doses of cocaine. Cocaine was also found in almost all the analyzed sample surfaces and also was found in nasal mucus of the police officers that were present during the manipulation of cocaine seizures without using a face mask. In summary, cocaine concentrations could present a health hazard to the employees and therefore warrants remediation and some modifications of the manipulation operations have been proposed. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:251 / 258
页数:8
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