Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing

被引：91
作者：
Desmet, Celine M. [1 ]
Preat, Veronique [2 ]
Gallez, Bernard [1 ]
机构：
[1] Catholic Univ Louvain, Louvain Drug Res Inst, Biomed Magnet Resonance Res Grp, Brussels, Belgium
[2] Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, Brussels, Belgium
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 129卷
关键词：
Wound healing; Oxygenation; Perfusion; Diabetes; Growth factors; Nanomedicines; Gene therapy; Skin; ELECTRON-PARAMAGNETIC-RESONANCE; OXIDE-RELEASING NANOPARTICLES; HYPOXIA-INDUCIBLE FACTOR; DIABETIC FOOT ULCERS; SKIN FLAP SURVIVAL; NITRIC-OXIDE; FACTOR-BB; STIMULATES ANGIOGENESIS; INCREASES SURVIVAL; COLLAGEN-SYNTHESIS;
D O I：
10.1016/j.addr.2018.02.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing impairment; therefore, treatments to improve hemodynamics and increase wound oxygenation are of particular interest for the treatment of chronic wounds. This article describes the roles of oxygen and angiogenesis in wound healing as well as the tools used to evaluate tissue oxygenation and perfusion and then presents a review of nanomedicines and gene therapies designed to improve perfusion and oxygenation and accelerate wound healing. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：262 / 284
页数：23
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