Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

被引：115

作者：

Boire, Adrienne ^{[1
]}

Brandsma, Dieta ^{[2
]}

Brastianos, Priscilla K. ^{[3
,4
,5
]}

Le Rhun, Emilie ^{[6
]}

Ahluwalia, Manmeet ^{[7
]}

Junck, Larry ^{[8
]}

Glantz, Michael ^{[9
]}

Groves, Morris D. ^{[10
,11
]}

Lee, Eudocia Q. ^{[5
,12
]}

Lin, Nancy ^{[5
,13
]}

Raizer, Jeffrey ^{[14
,15
]}

Ruda, Roberta ^{[16
,17
]}

Weller, Michael ^{[18
]}

van den Bent, Martin J. ^{[19
,20
]}

Vogelbaum, Michael A. ^{[21
]}

Chang, Susan ^{[22
]}

Wen, Patrick Y. ^{[5
,23
]}

Soffietti, Riccardo ^{[16
,17
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Neurol, 1275 York Ave, New York, NY 10021 USA

[2] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Neurooncol, Amsterdam, Netherlands

[3] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Univ Hosp, Dept Neurooncol Neurosurg, Lille, France

[7] Cleveland Clin, Neurol Inst, Dept Med, Cleveland, OH 44106 USA

[8] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

[9] Penn State Hlth, Dept Neurosurg, Hershey, PA USA

[10] Austin Brain Tumor Ctr, Dept Neurooncol, Austin, TX USA

[11] Univ Texas Austin, Austin, TX 78712 USA

[12] Brigham & Womens Hosp, Dept Neurol, 75 Francis St, Boston, MA 02115 USA

[13] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[14] Northwestern Univ, Dept Neurol, Chicago, IL 60611 USA

[15] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[16] Univ Turin, Dept Neurooncol, Turin, Italy

[17] City Hlth & Sci Hosp, Turin, Italy

[18] Univ Hosp, Dept Neurol, Zurich, Switzerland

[19] Erasmus MC, Ctr Canc, Brain Tumor Ctr, Rotterdam, Netherlands

[20] Univ Rotterdam, Rotterdam, Netherlands

[21] Cleveland Clin, Brain Tumor & Neurooncol Ctr, Cleveland, OH 44106 USA

[22] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA

[23] Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02115 USA

来源：

NEURO-ONCOLOGY | 2019年 / 21卷 / 05期

关键词：

circulating tumor cells; clinical implications; CNS metastases; ctDNA; liquid biopsy; CIRCULATING TUMOR-CELLS; BREAST-CANCER PATIENTS; CEREBROSPINAL-FLUID; LEPTOMENINGEAL METASTASIS; FLOW-CYTOMETRY; RESPONSE ASSESSMENT; BRAIN METASTASES; SOLID TUMORS; ACQUIRED-RESISTANCE; POOLED ANALYSIS;

D O I：

10.1093/neuonc/noz012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.

引用

页码：571 / 583

页数：13

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