Failure of radiation therapy for brain involvement in Erdheim Chester disease

被引：35

作者：

Mascalchi, M

Nencini, P

Nistri, M

Sarti, C

Santoni, R

机构：

[1] Univ Florence, Dipartimento Fisiopatol Clin, Sez Radiodiagnost, I-50134 Florence, Italy

[2] Univ Florence, Clin Neurol 3, I-50134 Florence, Italy

来源：

JOURNAL OF NEURO-ONCOLOGY | 2002年 / 59卷 / 02期

关键词：

Erdheim Chester disease; histiocytosis; proton MR spectroscopy; brain stem;

D O I：

10.1023/A:1019649201324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with suprasellar and brain stem involvement in Erdheim Chester disease (ECD) underwent magnetic resonance (MR) imaging and proton MR spectroscopy (H-1 MRS) of the ventral pons before and 1, 4 and 18 months after external whole-brain (24 Gy) radiotherapy. By revealing a decrease of the N-acetyl-aspartate/choline ratio in the pons, H-1 MR spectroscopy anticipated lesions growth on MR imaging. In line with the results in four patients reported in the literature, our observation indicates that external radiation therapy is not effective for intracranial involvement in ECD.

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收藏

页码：169 / 172

页数：4

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