Detection of diffuse axonal injury in forensic pathology

被引：3

作者：

Hostiuc, Sorin ^{[1
,2
]}

Pirici, Daniel ^{[3
]}

Negoi, Ionut ^{[4
,5
]}

Ion, Daniela Adriana ^{[6
]}

Ceausus, Mihai ^{[7
,8
]}

机构：

[1] Natl Inst Legal Med, Bucharest, Romania

[2] Carol Davila Univ Med & Pharm, Dept Legal Med & Bioeth, Bucharest, Romania

[3] Univ Med & Pharm Craiova, Dept Morphol, Res Ctr Microscop Morphol & Immunol, Craiova, Romania

[4] Floreasca Clin Emergency Hosp, Bucharest, Romania

[5] Carol Davila Univ Med & Pharm, Dept Surg, Bucharest, Romania

[6] Carol Davila Univ Med & Pharm, Dept Physiol, Bucharest, Romania

[7] Natl Inst Legal Med, Bucharest, Romania

[8] Carol Davila Univ Med & Pharm, Dept Pathol, Bucharest, Romania

来源：

ROMANIAN JOURNAL OF LEGAL MEDICINE | 2014年 / 22卷 / 03期

关键词：

diffuse axonal injury; beta-APP; ubiquitin; forensic pathology; AMYLOID PRECURSOR PROTEIN; WHITE MATTER; BRAIN-INJURY; HEAD-INJURY; KINASE; DAMAGE; NEUROPATHOLOGY; PATHOBIOLOGY; DIAGNOSIS; ANIMALS;

D O I：

10.4323/rjlm.2014.145

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Even if beta APP remains the gold standard in identifying diffuse axonal injuries, other histological, ultrastructure, histochemical, or immunohistochemical markers may aid the diagnosis and may better characterize this traumatic brain pathology. Moreover, associated changes, including neuronal body changes, the presence of microglial clusters, and so on, when identified in a traumatic context, should suggest at least the need of using specific markers for identification of DAIs. The purpose of this article is to present the main microscopy techniques used in forensic practice to detect diffuse axonal injury.

引用

页码：145 / 152

页数：8

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