Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice

被引：0

作者：

Liu, Wei ^{[1
]}

Shan, Li-Ping ^{[2
]}

Dong, Xue-Song ^{[1
]}

Liu, Zhi ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Emergency, Shenyang, Peoples R China

[2] China Med Univ, Shengjing Hosp, Dept Urol Surg, Shenyang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Paraquat; poisoning; acute lung injury; Toll-like receptor 4; inflammation; HEAT-SHOCK-PROTEIN-60; MUTATIONS; TOXICITY;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To investigate the possible relationship and mechanism of Toll-like receptor 4 (TLR4) and acute lung injury induced by paraquat (PQ) poisoning. Methods: Male wild type mice and male TLR4-knockout mice were used in this study. After paraquat treatment for 24 hours, mice were euthanized and pathology, TLR4 expression and pro-inflammatory cytokines were evaluated. Results: Wild type mice showed deteriorated lung injury, pathological damages and increased TLR4 expression and pulmonary TNF-alpha, IL-1 beta and NF-kappa B p65 levels after PQ treatment. TLR4-deficient mice were significantly resistant to paraquat-induced lung injury. Conclusion: TLR4 may be required as a mediator and may play an important role in acute lung injury induced by paraquat.

引用

页码：3392 / 3397

页数：6

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