Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice

被引：0
作者：
Liu, Wei [1 ]
Shan, Li-Ping [2 ]
Dong, Xue-Song [1 ]
Liu, Zhi [1 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Dept Emergency, Shenyang, Peoples R China
[2] China Med Univ, Shengjing Hosp, Dept Urol Surg, Shenyang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Paraquat; poisoning; acute lung injury; Toll-like receptor 4; inflammation; HEAT-SHOCK-PROTEIN-60; MUTATIONS; TOXICITY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: To investigate the possible relationship and mechanism of Toll-like receptor 4 (TLR4) and acute lung injury induced by paraquat (PQ) poisoning. Methods: Male wild type mice and male TLR4-knockout mice were used in this study. After paraquat treatment for 24 hours, mice were euthanized and pathology, TLR4 expression and pro-inflammatory cytokines were evaluated. Results: Wild type mice showed deteriorated lung injury, pathological damages and increased TLR4 expression and pulmonary TNF-alpha, IL-1 beta and NF-kappa B p65 levels after PQ treatment. TLR4-deficient mice were significantly resistant to paraquat-induced lung injury. Conclusion: TLR4 may be required as a mediator and may play an important role in acute lung injury induced by paraquat.
引用
收藏
页码：3392 / 3397
页数：6
相关论文
共 23 条
[1]   Mammalian Toll-like receptors [J].
Akira, S .
CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (01) :5-11
[2]   Deaths from pesticide poisoning: a global response [J].
Bertolote, J. M. ;
Fleischmann, A. ;
Eddleston, M. ;
Gunnell, D. .
BRITISH JOURNAL OF PSYCHIATRY, 2006, 189 :201-203
[3]   Chlamydial heat shock protein 60 activates macrophages and endothelial cells through toll-like receptor 4 and MD2 in a MyD88-dependent pathway [J].
Bulut, Y ;
Faure, E ;
Thomas, L ;
Karahashi, H ;
Michelsen, KS ;
Equils, O ;
Morrison, SG ;
Morrison, RP ;
Arditi, M .
JOURNAL OF IMMUNOLOGY, 2002, 168 (03) :1435-1440
[4]   Treatment of acute paraquat intoxication using recommended megadose of vitamin C: A reappraisal [J].
Chang, J. -B. ;
Lin, C. -C. ;
Chiou, J. -F. ;
Mau, S. -Y. ;
Liu, T. -Z. ;
Chen, C. -H. .
FREE RADICAL RESEARCH, 2013, 47 (12) :991-1001
[5]   Lung toxicity of paraquat in the rat [J].
Chen, CM ;
Lua, AC .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 2000, 60 (07) :477-487
[6]   Paraquat poisonings:: Mechanisms of lung toxicity, clinical features, and treatment [J].
Dinis-Oliveira, R. J. ;
Duarte, J. A. ;
Sanchez-Navarro, A. ;
Remiao, F. ;
Bastos, M. L. ;
Carvalho, F. .
CRITICAL REVIEWS IN TOXICOLOGY, 2008, 38 (01) :13-71
[7]   Kinetics of paraquat in the isolated rat lung: Influence of sodium depletion [J].
Dinis-Oliveira, R. J. ;
De Jesus Valle, M. J. ;
Bastos, M. L. ;
Carvalho, F. ;
Navarro, A. Sanchez .
XENOBIOTICA, 2006, 36 (08) :724-737
[8]   TOLL-LIKE RECEPTOR 4-DEPENDENT RESPONSES TO LUNG INJURY IN A MURINE MODEL OF PULMONARY CONTUSION [J].
Hoth, J. Jason ;
Wells, Jonathan D. ;
Brownlee, Noel A. ;
Hiltbold, Elizabeth M. ;
Meredith, J. Wayne ;
McCall, Charles E. ;
Yoza, Barbara K. .
SHOCK, 2009, 31 (04) :376-381
[9]   Role of growth factors in acute lung injury induced by paraquat in a rat model [J].
Jian, Xiangdong ;
Li, Ming ;
Zhang, Yijing ;
Ruan, Yanjun ;
Guo, Guangran ;
Sui, Hong ;
Zhang, Yuanchao .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2011, 30 (06) :460-469
[10]   Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components [J].
Laflamme, N ;
Rivest, S .
FASEB JOURNAL, 2001, 15 (01) :155-163
123