In vivo anti-malarial effect of the A-amino alcohol 1t on Plasmodium berghei

被引：3

作者：

Bahamontes-Rosa, N. ^{[1
]}

Bucher, K. ^{[1
]}

Held, J. ^{[1
]}

Robin, A. ^{[2
]}

Hoffmann, W. H. ^{[1
]}

Flitsch, S. L. ^{[2
]}

Kremsner, P. G. ^{[1
,3
]}

Kun, J. F. J. ^{[1
]}

机构：

[1] Univ Tubingen, Dept Parasitol, Inst Trop Med, D-72074 Tubingen, Germany

[2] Univ Manchester, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England

[3] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon

来源：

PARASITOLOGY RESEARCH | 2009年 / 104卷 / 06期

关键词：

MALARIA PARASITES; CEREBRAL MALARIA; AQUAGLYCEROPORIN; DISEASE;

D O I：

10.1007/s00436-009-1348-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Glycerol derivatives are a class of compounds, which are easy and inexpensive to produce with potent anti-malarial activities against blood stages of Plasmodium falciparum in vitro. In the present study, one of these compounds, termed 1t, which had the lowest IC50 values, was assessed in a murine malarial model. Nuclear magnetic resonance imaging and Balb/c mice infected with Plasmodium berghei ANKA strain were treated in a 4-day suppressive test. Mice received a once-daily intraperitoneal administration of 50 mg/Kg of the drug for 4 days. Although no parasitaemia clearance was reached, a slower parasite proliferation and a slightly longer survival time compared with the placebo group were observed.

引用

页码：1459 / 1464

页数：6

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