Modulation of pituitary adenylate cyclase-activating polypeptide (PACAP) expression in explant-cultured guinea pig cardiac neurons

被引：2

作者：

Girard, Beatrice M. ^{[1
]}

Young, Beth A. ^{[1
]}

Buttolph, Thomas R. ^{[1
]}

White, Sheryl L. ^{[1
]}

Parsons, Rodney L. ^{[1
]}

机构：

[1] Univ Vermont, Coll Med, Dept Anat & Neurobiol, Burlington, VT 05405 USA

来源：

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY | 2006年 / 1070卷

关键词：

pituitary adenylate cyclase-activating polypeptide; cardiac neurons; trophic factors;

D O I：

10.1196/annals.1317.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pituitary adenylate cyclase-activating polypeptide (PACAP) expression was quantified in explant-cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP-immunoreactive neurons and pro-PACAP transcript levels increased significantly. Treatment with neurturin or glial-derived neurotrophic factor significantly suppressed the percentage of PACAP-IR neurons, but not pro-PACAP transcript levels.

引用

页码：298 / 302

页数：5

共 5 条

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Rossingol, TM ;

Girard, BM ;

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Parsons, RL .

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[3]

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[4]

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[5]

Vaudry D, 2000, PHARMACOL REV, V52, P269

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