Enantioselective Synthesis of Tetrahydroquinolines via One-Pot Cascade Biomimetic Reduction

被引：12

作者：

Zhao, Zi-Biao ^{[1
]}

Li, Xiang ^{[1
]}

Chen, Mu-Wang ^{[1
]}

Wu, Bo ^{[1
]}

Zhou, Yong-Gui ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Liaoning, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2020年 / 38卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Biomimetic synthesis; Chirality; Reduction; Tetrahydroquinoline; One-pot; BRONSTED ACID CATALYSIS; HYDROAMINATION/ASYMMETRIC TRANSFER HYDROGENATION; ASYMMETRIC TRANSFER HYDROGENATION; NAD(P)H MODEL; QUINOLINES; CONSTRUCTION; LIGANDS; COMPLEX; ACCESS; SERIES;

D O I：

10.1002/cjoc.202000409

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Summary of main observation and conclusion A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one-pot cascade biomimetic reduction. The detailed reaction pathway includes the acid-catalyzed and ruthenium-catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.

引用

页码：1691 / 1695

页数：5

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