Copper-Catalyzed Oxidative Alkylation of Vinylic Cβ-H of Enamides with Cyclic Ethers

被引：15

作者：

Ding, R. ^{[1
]}

Lu, Wang-Gang ^{[1
]}

Ci, Hao ^{[1
]}

Mao, Yue-Yuan ^{[1
]}

Liu, Lei ^{[1
]}

机构：

[1] Anhui Sci & Technol Univ, Coll Chem & Mat Engn, Bengbu 233000, Anhui, Peoples R China

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 23期

基金：

中国国家自然科学基金;

关键词：

alkylation; cyclic ethers; enamides; multi-substituted alkene; vinylic; CROSS-COUPLING REACTIONS; METAL-FREE; BOND FUNCTIONALIZATION; C(SP(3))-H BOND; BENZYL ETHERS; ADJACENT; ALPHA; TETRAHYDROFURAN; ESTERIFICATION; OXYALKYLATION;

D O I：

10.1002/slct.201901837

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general strategy for the oxidative alkylation of vinylic C-beta-H bond of enamides catalyzed by copper to prepare structurally diverse ethers was developed. Under standard reaction conditions, various cyclic and acyclic enamides reacted well with cyclic ethers to afford the corresponding multi-substituted alkene products in good yields. In addition, the coupling products could be converted into useful amino alcohol derivatives. The coupling reaction was considered to follow a mechanism based on radical pathway.

引用

页码：6954 / 6957

页数：4

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