Cancer-associated fibroblasts in acute leukemia

被引：5
作者：
Gu, Ling [1 ,2 ,3 ,4 ]
Liao, Ping [5 ,6 ,7 ]
Liu, Hanmin [1 ,2 ,3 ,4 ,8 ]
机构：
[1] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China
[2] Sichuan Univ, West China Univ Hosp 2, Joint Lab Lung Dev & Related Dis, Chengdu, Peoples R China
[3] Sichuan Univ, Sch Life Sci Fudan Univ, West China Univ Hosp 2, West China Inst Women & Childrens Hlth, Chengdu, Peoples R China
[4] Sichuan Univ, NHC Key Lab Chronobiol, Chengdu, Peoples R China
[5] Natl Neurosci Inst, Calcium Signalling Lab, Singapore, Singapore
[6] Duke NUS Med Sch, Acad & Clin Dev, Singapore, Singapore
[7] Singapore Inst Technol, Hlth & Social Sci, Singapore, Singapore
[8] Sichuan Univ, West China Univ Hosp 2, Sichuan Birth Defects Clin Res Ctr, Chengdu, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
bone marrow; tumor microenvironment; leukemia; relapsed; refractory; cancer associated fibroblasts; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELL; ACUTE MYELOID-LEUKEMIA; BONE-MARROW FIBROSIS; ACUTE MYELOGENOUS LEUKEMIA; MESENCHYMAL STROMAL CELLS; SINGLE-CELL; T-CELLS; MYELODYSPLASTIC SYNDROME; ACTIVATION PROTEIN;
D O I：
10.3389/fonc.2022.1022979
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although the prognosis for acute leukemia has greatly improved, treatment of relapsed/refractory acute leukemia (R/R AL) remains challenging. Recently, increasing evidence indicates that the bone marrow microenvironment (BMM) plays a crucial role in leukemogenesis and therapeutic resistance; therefore, BMM-targeted strategies should be a potent protocol for treating R/R AL. The targeting of cancer-associated fibroblasts (CAFs) in solid tumors has received much attention and has achieved some progress, as CAFs might act as an organizer in the tumor microenvironment. Additionally, over the last 10 years, attention has been drawn to the role of CAFs in the BMM. In spite of certain successes in preclinical and clinical studies, the heterogeneity and plasticity of CAFs mean targeting them is a big challenge. Herein, we review the heterogeneity and roles of CAFs in the BMM and highlight the challenges and opportunities associated with acute leukemia therapies that involve the targeting of CAFs.
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页数：12
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