Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis

被引：41
作者：
Di Nunno, Vincenzo [1 ]
Mollica, Veronica [1 ]
Gatto, Lidia [1 ]
Santoni, Matteo [2 ]
Cosmai, Laura [3 ]
Porta, Camillo [4 ,5 ]
Massari, Francesco [1 ]
机构：
[1] St Orsola Marcello Malpighi Hosp, Div Oncol, Bologna, Italy
[2] Macerata Hosp, Oncol Unit, Macerata, Italy
[3] San Carlo Borromeo Hosp, Div Nephrol & Dialysis, ASST Santi Paolo & Carlo, Onconephrol Outpatient Clin, Milan, Italy
[4] Univ Pavia, Dept Internal Med, Pavia, Italy
[5] IRCCS, Div Traslat Oncol, Ist Clin Sci Maugeri, Pavia, Italy
来源：
IMMUNOTHERAPY | 2019年 / 11卷 / 07期
关键词：
localized RCC; meta-analysis; metastatic RCC; neutrophil-lymphocyte ratio; predictive factor; prognostic factor; renal cell carcinoma; systematic review; PRETREATMENT NEUTROPHIL; TARGETED THERAPY; SOLID TUMORS; SURVIVAL; CANCER; PREDICT; INFLAMMATION; VALIDATION; RECURRENCE; EVEROLIMUS;
D O I：
10.2217/imt-2018-0175
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aim: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. Methods: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/ metastatic RCC. Results: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I-2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.422.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. Conclusion: The NLR ratio is a variable correlated to prognosis in RCC patients.
引用
收藏
页码：631 / 643
页数：13
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