The synthesis of antioxidants showing selective affinity for low density lipoproteins

被引：24

作者：

Brown, DW ^{[1
]}

Mahon, MF ^{[1
]}

Ninan, A ^{[1
]}

Sainsbury, M ^{[1
]}

机构：

[1] UNIV BATH,SCH CHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 16期

关键词：

D O I：

10.1039/a701948c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of some novel indolinosteroids, indolinodecalins and spiro tetrahydroquinolinopiperidines are described. These compounds act as chain-breaking antioxidants and In some cases show very selective binding to LDL particles in human plasma. Aspects of the stereoselectivity in the Fischer indolisation of three common steroidal ketones and the reduction of the resultant indoles to indolines are considered.

引用

页码：2329 / 2336

页数：8

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