MAGRIT: The Largest-Ever Phase III Lung Cancer Trial Aims to Establish a Novel Tumor-Specific Approach to Therapy

被引：134

作者：

Tyagi, Preeta ^{[1
]}

Mirakhur, Beloo ^{[1
]}

机构：

[1] GlaxoSmithKline Oncol, Collegeville, PA 19426 USA

来源：

CLINICAL LUNG CANCER | 2009年 / 10卷 / 05期

关键词：

Antigen-specific cancer immunotherapeutics; Biomarkers; Cytolytic T cells; MAGE-A3; Relapse; MELANOMA; PEPTIDE; VACCINES; CELLS;

D O I：

10.3816/CLC.2009.n.052

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This clinical trial summary provides the background and rationale for a randomized trial, MAGRIT, to investigate the efficacy of MAGE-A3 antigen-specific cancer immunotherapeutic (ASCI) agents in preventing cancer relapse, when administered after tumor resection, in patients with MAGE-M-positive stages IB, II, and IIIA non-small-cell lung cancer. The study will also evaluate potential side effects of MAGE-A3 ASCIs. The primary endpoint is disease-free survival. The secondary endpoint is prospective validation of the gene signature predictive of benefit from MAGE-A3 ASCI therapy.

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收藏

页码：371 / 374

页数：4

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