The palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with alkyl halides.: An entry into 2-substituted 3-alkylindoles

被引：0
作者：
Arcadi, A
Cacchi, S
Fabrizi, G
Marinelli, F
机构：
[1] Univ Rome La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, I-00185 Rome, Italy
[2] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, Fac Sci, I-67100 Laquila, Italy
来源：
SYNLETT | 2000年 / 03期
关键词：
3-alkylindoles; alkynes; cyclization; palladium; alkyl halides;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepared usually in good yield through the palladium-catalyzed reaction of o-alkynyltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best results are obtained by employing Pd-2(dba)(3) and tris(2,4,6-trimethoxyphenyl)phosphine in THF.
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收藏
页码：394 / 396
页数：3
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