Design and function of transcriptional switches in Drosophila

被引：14
作者：
Arnosti, DN [1 ]
机构：
[1] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA
来源：
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2002年 / 32卷 / 10期
关键词：
transcription; enhancer; promoter; promoter specificity; boundary element; insulator; polycomb; trithorax;
D O I：
10.1016/S0965-1748(02)00089-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extensive genetic and biochemical analysis of Drosophila melanogaster has made this system an important model for characterization of transcriptional regulatory elements and factors. Given the striking conservation of transcriptional controls in metazoans, general principles derived from studies of Drosophila are expected to continue to illuminate transcriptional regulation in other systems, including vertebrates. With improvement in technologies for genetic manipulation of insects, research in Drosophila will also aid the design of systems for controlled expression of genes in other hosts. This review focuses on recent advances from Drosophila in analysis of the functional components of transcriptional switches, including basal promoters, enhancers, boundary elements, and maintenance elements. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1257 / 1273
页数：17
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