Determination of absolute configuration of C14-C23 fragment in symbiodinolide

被引：19
作者：
Han, Chunguang [1 ]
Yamano, Yoshi [1 ]
Kita, Masaki [2 ]
Takamura, Hiroyoshi [1 ]
Uemura, Daisuke [1 ,3 ]
机构：
[1] Nagoya Univ, Dept Chem, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[2] Univ Tsukuba, Dept Chem, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058571, Japan
[3] Keio Univ, Dept Biosci & Informat, Fac Sci & Technol, Yokohama, Kanagawa 2238522, Japan
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 37期
关键词：
Ethenolysis; 2nd-generation Hoveyda-Grubbs catalyst; Absolute configuration; J-based configuration analysis; NATURAL-PRODUCTS; METATHESIS; DIOLS;
D O I：
10.1016/j.tetlet.2009.07.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The degradation product C14-C23 2 was obtained using ethenolysis with the 2nd-generation Hoveyda-Grubbs catalyst from 62-membered lactone in symbiodinolide (1). The absolute configurations of three chiral centers in fragment 2 were assigned as 17R, 18R, and 21R by a combination of J-based configuration analysis and the Mosher-Riguera method. (c) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：5280 / 5282
页数：3
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