Larvicide Activity on Aedes aegypti of Essential Oil Nanoemulsion from the Protium heptaphyllum Resin

被引：16

作者：

Faustino, Cleidjane Gomes ^{[1
]}

de Medeiros, Fernando Antonio ^{[2
]}

Ribeiro Galardo, Allan Kardec ^{[3
]}

Lobato Rodrigues, Alex Bruno ^{[4
]}

Lopes Martins, Rosany ^{[4
]}

de Medeiros Souza Lima, Yuri ^{[2
]}

Fechine Tavares, Josean ^{[5
]}

Alves de Medeiros, Marcos Antonio ^{[6
,7
]}

dos Santos Cruz, Jader ^{[8
]}

de Almeida Sheylla, Susan Moreira da Silva ^{[1
,4
]}

机构：

[1] Univ Fed Amapa, Lab Pharmacognosy & Phytochem, Postgrad Program Pharmaceut Innovat, Highway Juscelino Kubitschek,Km 02, BR-68903197 Macapa, Brazil

[2] Univ Fed Amapa, Postgrad Program Hlth Sci, Highway Juscelino Kubitschek,Km 02, BR-68903197 Macapa, Brazil

[3] Inst Sci & Technol Res State Amapa, Highway Juscelino Kubitschek,Km 10, BR-68903419 Macapa, Brazil

[4] Univ Fed Amapa, Lab Pharmacognosy & Phytochem, Postgrad Program Biodivers & Biotechnol Network, Highway Juscelino Kubitschek,Km 02, BR-68902280 Macapa, Brazil

[5] Univ Fed Paraiba, Postgrad Program Nat & Synthet Prod, Cidade Univ, BR-58051900 Joao Pessoa, Paraiba, Brazil

[6] Nova Esperanca FAMENE Sch Med, BR-58067695 Joao Pessoa, Paraiba, Brazil

[7] Fac Med Sci Paraiba FCM, BR 230,Km 9, BR-58310000 Intermares, Paraiba, Brazil

[8] Univ Fed Minas Gerais, Postgrad Program Biochem & Immunol, Ave Antonio Coelho, BR-31270901 Belo Horizonte, MG, Brazil

来源：

MOLECULES | 2020年 / 25卷 / 22期

关键词：

colloidal system; natural compounds; nanotechnology; NANO-EMULSION FORMATION; EMULSIFICATION METHODS; EXTRACTS; LEAVES;

D O I：

10.3390/molecules25225333

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this work was to prepare a nanoemulsion containing the essential oil of Protium heptaphyllum resin and to evaluate the larvicidal activity and the residual larvicidal effect against Aedes aegypti. The essential oil was identified by gas chromatography coupled to a mass spectrometer, and the nanoemulsions were prepared using a low-energy method and characterized by photon correlation spectroscopy. The results indicated the major constituents as p-cimene (27.70%) and alpha-Pinene (22.31%). Nanoemulsions had kinetic stability and a monomodal distribution in a hydrophilic-lipophilic balance of 14 with particle diameters of 115.56 +/- 1.68 nn and zeta potential of -29.63 +/- 3.46 mV. The nanoemulsion showed larvicidal action with LC50 = 2.91 mu g center dot mL(-1) and residual larvicidal effect for 72 h after application to A. aegypti larvae. Consequently, the nanobiotechnological product derived from the essential oil of P. heptaphyllum resin could be used against infectious disease vectors.

引用

页数：12

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