From sequence to chromosome:: The tip of the X chromosome of D. melanogaster

被引：21

作者：

Benos, PV

Gatt, MK

Ashburner, M

Murphy, L

Harris, D

Barrell, B

Ferraz, C

Vidal, S

Brun, C

Demailles, J

Cadieu, E

Dreano, S

Gloux, S

Lelaure, V

Mottier, S

Galibert, F

Borkova, D

Minana, B

Kafatos, FC

Louis, C

Sidén-Kiamos, I

Bolshakov, S

Papagiannakis, G

Spanos, L

Cox, S

Madueño, E

de Pablos, B

Modolell, J

Peter, A

Schöttler, P

Werner, M

Mourkioti, F

Beinert, N

Dowe, G

Schäfer, U

Jäckle, H

Bucheton, A

Callister, DM

Campbell, LA

Darlamitsou, A

Henderson, NS

McMillan, PJ

Salles, C

Tait, EA

Valenti, P

Saunders, RDC

Glover, DM

机构：

[1] European Bioinformat Inst, Cambridge CB10 1SD, England

[2] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[3] Sanger Ctr, Cambridge CB10 1SA, England

[4] Univ Montpellier, Sch Med, IGH, CNRS, F-34396 Montpellier 5, France

[5] Fac Med, CNRS, Unite Propre Rech 41, F-35043 Rennes, France

[6] European Mol Biol Lab, Heidelberg, Germany

[7] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Heraklion, Greece

[8] Univ Crete, Dept Biol, Heraklion, Greece

[9] Univ Autonoma Madrid, E-28049 Madrid, Spain

[10] CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[11] Max Planck Inst Biophys Chem, Dept Mol Dev Biol, D-37070 Gottingen, Germany

[12] Univ Dundee, Dept Anat & Physiol, Canc Res Campaign, Cell Cycle Genet Grp, Dundee DD1 4HN, Scotland

[13] Open Univ, Dept Biol Sci, Milton Keynes MK7 6AA, Bucks, England

来源：

SCIENCE | 2000年 / 287卷 / 5461期

关键词：

D O I：

10.1126/science.287.5461.2220

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a Long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.

引用

页码：2220 / 2222

页数：3

共 32 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2]

Ashburner M, 1999, GENETICS, V153, P179

[3]

Ashburner M., 1989, DROSOPHILA LAB HDB

[4] DIE PUFFS DER SPEICHELDRUSENCHROMOSOMEN VON DROSOPHILA MELANOGASTER .1. BEOBACHTUNGEN ZUM VERHLATEN DES PUFFMUSTERS IM NORMALSTAMM UND BEI ZWEI MUTANTEN, GIANT UND LETHAL-GIANT-LARVAE [J].

BECKER, HJ .

CHROMOSOMA, 1959, 10 (06) :654-678

[5]

BRIDGES C. B., 1937, Cytologia, P745, DOI 10.1508/cytologia.FujiiJubilaei.745

[6] A revised map of the salivary gland X-chromosome of Drosophila melanogaster [J].

Bridges, CB .

JOURNAL OF HEREDITY, 1938, 29 (01) :11-13

[7] Salivary chromosome maps with a key to the banding of the chromosomes of Drosophila melanogaster [J].

Bridges, CB .

JOURNAL OF HEREDITY, 1935, 26 (02) :60-64

[8]

Carson Hampton L., 1992, P441

[9] A STUDY OF 10 FAMILIES OF TRANSPOSABLE ELEMENTS ON X-CHROMOSOMES FROM A POPULATION OF DROSOPHILA-MELANOGASTER [J].

CHARLESWORTH, B ;

LAPID, A .

GENETICS RESEARCH, 1989, 54 (02) :113-125

[10] A SUPERFAMILY OF DROSOPHILA-SATELLITE RELATED (SR) DNA REPEATS RESTRICTED TO THE X-CHROMOSOME EUCHROMATIN [J].

DIBARTOLOMEIS, SM ;

TARTOF, KD ;

JACKSON, FR .

NUCLEIC ACIDS RESEARCH, 1992, 20 (05) :1113-1116

← 1 2 3 4 →