Short-term and long-term modulation of gene expression by antisense therapeutics

被引：22
|
作者：
Sazani, P
Vacek, MM
Kole, R
机构：
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 05期
关键词：
D O I：
10.1016/S0958-1669(02)00366-X
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNase H degradation of target RNA are needed, In addition to short-term oligonucleotide effects, long term gene regulation can be accomplished by intracellularly expressed antisense RNAs delivered by viral vectors.
引用
收藏
页码：468 / 472
页数：5
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