Rapamycin, proliferation and geroconversion to senescence

被引：42
作者：
Blagosklonny, Mikhail V. [1 ]
机构：
[1] Roswell Park Canc Inst, Cell Stress Biol, Buffalo, NY 14263 USA
来源：
CELL CYCLE | 2018年 / 17卷 / 24期
关键词：
Aging; gero-suppressants; senolytics; rapalogs; cancer; SASP;
D O I：
10.1080/15384101.2018.1554781
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rapamycin inhibits cell proliferation, yet preserves (re)-proliferative potential (RPP). RPP is a potential of quiescent cells that is lost in senescent cells. mTOR drives conversion from quiescence to senescence (geroconversion). By suppressing geroconversion, rapamycin preserves RPP. Geroconversion is characterized by proliferation-like levels of phospho-S6K/S6/4E-BP1 in nonproliferating cells arrested by p16 and/or p21. mTOR-driven geroconversion is associated with cellular hyperfunction, which in turn leads to organismal aging manifested by age-related diseases.
引用
收藏
页码：2655 / 2665
页数：11
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