Characteristics and risk factors of infections following CD28-based CD19 CAR-T cells

被引：35

作者：

Dayagi, Talya Wittmann ^{[1
,2
]}

Sherman, Gilad ^{[1
,2
]}

Bielorai, Bella ^{[2
,3
]}

Adam, Etai ^{[3
]}

Besser, Michal J. ^{[2
,4
]}

Shimoni, Avichai ^{[2
,5
]}

Nagler, Arnon ^{[2
,5
]}

Toren, Amos ^{[2
,3
]}

Jacoby, Elad ^{[2
,3
]}

Avigdor, Abraham ^{[2
,5
]}

机构：

[1] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Dept Pediat, Ramat Gan, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Div Pediat Hematol & Oncol, Ramat Gan, Israel

[4] Sheba Med Ctr, Ella Inst Immunooncol, Ramat Gan, Israel

[5] Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Ramat Gan, Israel

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 07期

关键词：

CAR T-cells; leukemia; lymphoma; infections; cytokine-release syndrome;

D O I：

10.1080/10428194.2021.1881506

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CAR T-cells are approved for the treatment of relapsed and refractory leukemia and lymphoma. Here, we studied the infectious complications in 88 patients treated with CD28-based CD19 CAR T-cells. Overall, 36 infections were documented in 24 patients within the first month after CAR T-cell infusion: Six events of bacteremia, sixteen focal bacterial infections, and fourteen systemic or localized viral infections. Seven patients had nine infectious episodes beyond the first 30 days of follow-up, including three events of bacteremia, three focal bacterial, two viral and one fungal infection. The presence of neutropenia, neutropenic fever and lack of response to treatment were associated with a higher rate of infections. Children had less severe infections than adults. In a multivariate analysis lack of response to treatment was the only significant risk factor. Overall, the incidence of bacterial infections following CAR T-cells is modest especially in children and in patients responding to therapy.

引用

页码：1692 / 1701

页数：10

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