Immunosurveillance of senescent cancer cells by natural killer cells

被引：26
作者：
Iannello, Alexandre
Raulet, David H. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期
关键词：
NK cell; chemokine; NKG2D; senescence; p53;
D O I：
10.4161/onci.27616
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program.
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