Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis

被引：57

作者：

Garda, AL

Puelles, L

Rubenstein, JLR

Medina, L ^{[1
]}

机构：

[1] Univ Murcia, Fac Med, Dept Morphol Sci, E-30100 Murcia, Spain

[2] Miguel Hernandez Univ, Inst Neurosci, Alicante, Spain

[3] Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94143 USA

来源：

NEUROSCIENCE | 2002年 / 113卷 / 03期

关键词：

brain organizer; cortical hem; pallial-subpallial boundary; zona limitans intrathalamica; isthmic organizer; cerebellum;

D O I：

10.1016/S0306-4522(02)00171-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression patterns of the genes Wnt7b and Wnt8b were analyzed in the brain of chick embryos, having special emphasis in the forebrain. Our results indicated that, at early developmental stages, cWnt8b is expressed in the isthmic organizer and in other areas postulated as forebrain patterning centers, such as the avian cortical hem and the zona limitans intrathalamica (zli). Later in development, cWnt7b becomes expressed in regions neighboring and sometimes overlapping the cWnt8b domains, such as the thalamus on both sides of the zli, or the medial pallium adjacent to the cortical hem. This sequential expression of cWnt8b and cWnt7b is consistent with a role in the patterning and morphogenesis of these forebrain regions. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：689 / 698

页数：10