Protein Homeostasis at the Plasma Membrane

被引：36
作者：
Apaja, Pirjo M. [1 ,2 ]
Lukacs, Gergely L. [1 ,2 ,3 ]
机构：
[1] McGill Univ, Dept Physiol, Montreal, PQ, Canada
[2] McGill Univ, Res Grp Focused Prot Struct GRASP, Montreal, PQ, Canada
[3] McGill Univ, Dept Biochem, Montreal, PQ, Canada
来源：
PHYSIOLOGY | 2014年 / 29卷 / 04期
关键词：
TRANSMEMBRANE CONDUCTANCE REGULATOR; MARCH UBIQUITIN LIGASES; QUALITY-CONTROL; DOWN-REGULATION; ENDOPLASMIC-RETICULUM; MOLECULAR CHAPERONE; CLASS-I; SUBSTRATE-SPECIFICITY; N-GLYCOSYLATION; BINDING DOMAINS;
D O I：
10.1152/physiol.00058.2013
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.
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收藏
页码：265 / 277
页数：13
相关论文
共 154 条
[81]   Ubiquitin and Membrane Protein Turnover: From Cradle to Grave [J].
MacGurn, Jason A. ;
Hsu, Pi-Chiang ;
Emr, Scott D. .
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81, 2012, 81 :231-259
[82]   N-Glycan-mediated Quality Control in the Endoplasmic Reticulum Is Required for the Expression of Correctly Folded δ-Opioid Receptors at the Cell Surface [J].
Markkanen, Piia M. H. ;
Petaja-Repo, Ulla E. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (43) :29086-29098
[83]   Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy [J].
Marozkina, Nadzeya V. ;
Yemen, Sean ;
Borowitz, Molly ;
Liu, Lei ;
Plapp, Melissa ;
Sun, Fei ;
Islam, Rafique ;
Erdmann-Gilmore, Petra ;
Townsend, R. Reid ;
Lichti, Cheryl F. ;
Mantri, Sneha ;
Clapp, Phillip W. ;
Randell, Scott H. ;
Gaston, Benjamin ;
Zaman, Khalequz .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (25) :11393-11398
[84]   The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain [J].
Mattera, R ;
Tsai, YC ;
Weissman, AM ;
Bonifacino, JS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6874-6883
[85]   DYNAMICS OF GENE-EXPRESSION FOR A HIPPOCAMPAL GLYCOPROTEIN ELEVATED IN ALZHEIMERS-DISEASE AND IN RESPONSE TO EXPERIMENTAL LESIONS IN RAT [J].
MAY, PC ;
LAMPERTETCHELLS, M ;
JOHNSON, SA ;
POIRIER, J ;
MASTERS, JN ;
FINCH, CE .
NEURON, 1990, 5 (06) :831-839
[86]   Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway [J].
McNatt, Matthew W. ;
McKittrick, Ian ;
West, Matthew ;
Odorizzi, Greg .
MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (02) :697-706
[87]   CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control [J].
Min, Jin-Na ;
Whaley, Ryan A. ;
Sharpless, Norman E. ;
Lockyer, Pamela ;
Portbury, Andrea L. ;
Patterson, Cam .
MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (12) :4018-4025
[88]   Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 [J].
Mund, Thomas ;
Pelham, Hugh R. B. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (25) :11429-11434
[89]  
Narayan P, BIOCHEMISTRY, V51, P9270
[90]   The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases [J].
Nathan, James A. ;
Lehner, Paul J. .
EXPERIMENTAL CELL RESEARCH, 2009, 315 (09) :1593-1600
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