Protein Homeostasis at the Plasma Membrane

被引：36

作者：

Apaja, Pirjo M. ^{[1
,2
]}

Lukacs, Gergely L. ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Dept Physiol, Montreal, PQ, Canada

[2] McGill Univ, Res Grp Focused Prot Struct GRASP, Montreal, PQ, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ, Canada

来源：

PHYSIOLOGY | 2014年 / 29卷 / 04期

关键词：

TRANSMEMBRANE CONDUCTANCE REGULATOR; MARCH UBIQUITIN LIGASES; QUALITY-CONTROL; DOWN-REGULATION; ENDOPLASMIC-RETICULUM; MOLECULAR CHAPERONE; CLASS-I; SUBSTRATE-SPECIFICITY; N-GLYCOSYLATION; BINDING DOMAINS;

D O I：

10.1152/physiol.00058.2013

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.

引用

页码：265 / 277

页数：13

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