Y Chromosomes of 40% Chinese Descend from Three Neolithic Super-Grandfathers

被引：78

作者：

Yan, Shi ^{[1
,2
,3
]}

Wang, Chuan-Chao ^{[1
,2
]}

Zheng, Hong-Xiang ^{[1
,2
]}

Wang, Wei ^{[3
]}

Qin, Zhen-Dong ^{[1
,2
]}

Wei, Lan-Hai ^{[1
,2
]}

Wang, Yi ^{[1
,2
]}

Pan, Xue-Dong ^{[1
,2
]}

Fu, Wen-Qing ^{[1
,2
,5
]}

He, Yun-Gang ^{[3
]}

Xiong, Li-Jun ^{[4
]}

Jin, Wen-Fei ^{[3
]}

Li, Shi-Lin ^{[1
,2
]}

An, Yu ^{[1
,2
]}

Li, Hui ^{[1
,2
]}

Jin, Li ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[2] Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Minist Educ,Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China

[3] Chinese Acad Sci, SIBS, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China

[4] Fudan Univ, Inst Biomed Sci, Epigenet Lab, Shanghai 200433, Peoples R China

[5] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

PLOS ONE | 2014年 / 9卷 / 08期

基金：

美国国家科学基金会;

关键词：

SHORT READ ALIGNMENT; DNA-SEQUENCING DATA; GENOME SEQUENCE; EAST-ASIA; HAPLOGROUP TREE; NORTHERN CHINA; MODERN HUMANS; MUTATION-RATE; POPULATION; ORIGINS;

D O I：

10.1371/journal.pone.0105691

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Demographic change of human populations is one of the central questions for delving into the past of human beings. To identify major population expansions related to male lineages, we sequenced 78 East Asian Y chromosomes at 3.9 Mbp of the non-recombining region, discovered >4,000 new SNPs, and identified many new clades. The relative divergence dates can be estimated much more precisely using a molecular clock. We found that all the Paleolithic divergences were binary; however, three strong star-like Neolithic expansions at similar to 6 kya (thousand years ago) (assuming a constant substitution rate of 1x10(-9)/bp/year) indicates that similar to 40% of modern Chinese are patrilineal descendants of only three super-grandfathers at that time. This observation suggests that the main patrilineal expansion in China occurred in the Neolithic Era and might be related to the development of agriculture.

引用

页数：7

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