Manganese-Mediated Reductive Transamidation of Tertiary Amides with Nitroarenes

被引：120
作者：
Cheung, Chi Wai [1 ,2 ,3 ]
Ma, Jun-An [2 ,3 ]
Hu, Xile [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Inorgan Synth & Catalysis, ISIC LSCI,BCH 3305, CH-1015 Lausanne, Switzerland
[2] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 22期
基金：
中国国家自然科学基金;
关键词：
CATALYZED TRANSAMIDATION; SECONDARY AMIDES; PRIMARY CARBOXAMIDES; DIRECT AMIDATION; UREAS; ACID;
D O I：
10.1021/jacs.8b03739
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Amides are an important class of organic compounds, which have widespread industrial applications. Transamidation of amides is a convenient method to generate new amides from existing ones. Tertiary amides, however, are challenging substrates for transamidation. Here we describe an unconventional approach to the transamidation of tertiary amides using nitroarenes as the nitrogen source under reductive conditions. Manganese metal alone mediates the reactions and no additional catalyst is required. The method exhibits broad scope and high functional group tolerance.
引用
收藏
页码：6789 / 6792
页数：4
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