In vitro interaction of antifungal and antibacterial drugs against Cryptococcus neoformans var. grubii before and after capsular induction

被引：10
|
作者：
Rossato, Luana [1 ]
Loreto, Erico S. [2 ]
Venturini, Tarcieli P. [1 ]
Azevedo, Maria I. [4 ]
Weiblen, Carla [3 ]
Botton, Sonia A. [3 ]
Santurio, Janio M. [2 ]
Alves, Sydney H. [1 ]
机构：
[1] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Ciencias Farmaceut, BR-97119900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Farmacol, BR-97119900 Santa Maria, RS, Brazil
[3] Univ Fed Santa Maria, Programa Posgrad Med Vet, BR-97119900 Santa Maria, RS, Brazil
[4] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Vet, Porto Alegre, RS, Brazil
来源：
MEDICAL MYCOLOGY | 2015年 / 53卷 / 08期
关键词：
Antifungal; antibacterial; encapsulate; Cryptococcus neorformans var. grubii; interaction; AMPHOTERICIN-B; CANDIDA-ALBICANS; PYTHIUM-INSIDIOSUM; COMBINATION; AZITHROMYCIN; AGENTS; MINOCYCLINE; INFECTIONS; SUSCEPTIBILITY; FLUCONAZOLE;
D O I：
10.1093/mmy/myv059
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study evaluated the synergistic interactions between amphotericin B (AMB) and azithromycin (AZM), daptomycin (DAP), linezolid (LNZ), minocycline (MINO), fluconazole (FLZ), flucytosine (5FC), linezolid (LZD), or tigecycline (TIG) against clinical isolates of Cryptococcus neoformans var. grubii before and after capsule induction. High synergism (> 75%) was observed for the combinations, AMB+ 5FC, AMB+ TIG, AMB+ AZM, AMB+ LZD and AMB+ MINO but only in the strains after capsule induction. The results show that the presence of the capsule may lower theminimum inhibitory concentrations (MICs) of antifungal agents, but antimicrobial activity can be improved by combining antifungal and antibacterial agents.
引用
收藏
页码：885 / 889
页数：5
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