Design and Synthesis of Novel Functionalized Fused Oxazepine and Diazepine Analogues Containing Coumarin Backbone through Domino Reaction

A simple and straightforward approach has been developed for the synthesis of functionalized fused oxazepine and diazepine analogues containing coumarin backbone. The approach was done through three-component reaction of 4-chloro-3-formylcoumarin, triphenyl-lambda(5)-phosphanylidene derivatives and 2-aminophenol or o-phenylenediamine derivatives in the presence of cesium carbonate at room temperature. Carrying out the same reaction without base led to 4-aminoarylcoumarins. Mild reaction conditions and synthesis of fused functionalized heterocyclic backbones are advantages of this approach.