A new anti-inflammatory glucoside from Ficus racemosa L.

被引：66

作者：

Li, RW

Leach, DN

Myers, SP

Lin, GLD

Leach, GJ

Waterman, PG

机构：

[1] Univ Queensland, Australian Ctr Complmentary Med Educ & Res, Lismore, NSW, Australia

[2] So Cross Univ, Ctr Phytochem & Pharmacol, Lismore, NSW, Australia

[3] Parks & Wildlife Commiss No Terr, Palmerston, NT, Australia

来源：

PLANTA MEDICA | 2004年 / 70卷 / 05期

关键词：

Ficus racemosa; Moraceae; cyclooxybaenase-1 (COX-1); cyclooxygenase-2 (COX-2); 5-lipoxygenase (5-LOX); phospholipase A(2) (PA(2)); NMR; cytotoxicity; antioxidant;

D O I：

10.1055/s-2004-818969

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the ethanol extract of Ficus racemosa resulted in the identification of a new compound (rel)-4,6-dihydroxy-5-[3-methyl-(E)-propenoic acid-3-yl]-7-beta-glucopyranosyl-(2alpha,3beta-dihydrobenzofuran}-(3,2:b)-[4alpha,5beta-dihydroxy-6alpha-hydroxymethyltetrahydropyran](racemosic acid). Racemosic acid showed potent inhibitory activity against COX-1 and 5-LOX in vitro with IC50 values of 90 and 18 muM, respectively. Racemosic acid also demonstrated a strong antioxidant activity to scavenge ABTS free radical cations with an IC50 value Of 19 muM. In addition, cytotoxic effects of the extracts of F. racemosa were investigated in vitro using the ATP-based luminescence assay and results showed no cytotoxicity on the cell lines skin fibroblasts (1BR3), human Caucasian hepatocyte carcinoma (Hep G2) and human Caucasian promyelocytic leukaemia (HL-60). Bergenin was also isolated from the same active fraction.

引用

页码：421 / 426

页数：6

共 26 条

[1]

ANDREOTTI PE, 1995, CANCER RES, V55, P5276

[2]

BLAKE NM, 1998, NT BOT B, V23

[3] Anti-inflammatory drugs: New multitarget compounds to face an old problem. The dual inhibition concept [J].