The influence of air pollution on respiratory microbiome: A link to respiratory disease

被引：54

作者：

Xue, Yanfeng ^{[1
,2
,3
]}

Chu, Jiang ^{[2
]}

Li, Yunwei ^{[2
,4
]}

Kong, Xiangyang ^{[2
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China

[2] Kunming Univ Sci & Technol, Med Sch, 727 South Jingming Rd, Kunming 650500, Yunnan, Peoples R China

[3] Kunming Univ, Med Sch, Kunming, Yunnan, Peoples R China

[4] Kunming Childrens Hosp, Pharm Dept, Kunming, Yunnan, Peoples R China

来源：

TOXICOLOGY LETTERS | 2020年 / 334卷

关键词：

air pollution; particulate matter; microbiome; respiratory disease; dysbiosis; epithelial barrier damage; LUNG MICROBIOME; ANAEROBIC-BACTERIA; EPITHELIAL BARRIER; OXIDATIVE STRESS; EXPOSURE; EXACERBATIONS; PATHOGENESIS; INFLAMMATION; POPULATION; CELLS;

D O I：

10.1016/j.toxlet.2020.09.007

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Air pollution is known to trigger and exacerbate many respiratory diseases. The interaction between respiratory microbiome and host plays a significant role in maintaining airway immune homeostasis and health. Emerging evidence has revealed the associations of disturbances in the airway microbiome with air pollution and respiratory disease. However, respiratory microbiome has been an undervalued player in progressions of respiratory disease caused by air pollution. In this review, we summarize the current research advances with respect to the effects of air pollution on respiratory microbiome, then discuss the underlying mechanisms of air pollution induction of dysbiosis in respiratory microbiota and its links to respiratory diseases. This work may be helpful to deepening understanding the relationships between exposure, microbiome and airway disease and discovering new preventive and therapeutic strategies for air pollution-mediated respiratory disease.

引用

页码：14 / 20

页数：7

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