Anxiolytic and antioxidant effects of Euterpe oleracea Mart. (acai) seed extract in adult rat offspring submitted to periodic maternal separation

被引：16

作者：

de Bem, Graziele Freitas ^{[1
]}

Okinga, Anicet ^{[1
]}

Ognibene, Dayane Teixeira ^{[1
]}

da Costa, Cristiane Aguiar ^{[1
]}

Santos, Izabelle Barcellos ^{[1
]}

Soares, Ricardo Andrade ^{[1
]}

Beserra Silva, Dafne Lopes ^{[1
]}

Machado Rocha, Ana Paula ^{[2
]}

Fernandes, Jemima Isnardo ^{[3
]}

Fraga, Mabel Carneiro ^{[3
]}

Filgueiras, Claudio Carneiro ^{[3
]}

Manhaes, Alex Christian ^{[3
]}

de Moura, Roberto Soares ^{[1
]}

Resende, Angela Castro ^{[1
]}

机构：

[1] Univ Estado Rio De Janeiro, Inst Biol, Dept Pharmacol, BR-20551030 Rio De Janeiro, RJ, Brazil

[2] Univ Fed Juiz de Fora, Inst Biol Sci, Dept Physiol, BR-36036900 Juiz De Fora, MG, Brazil

[3] Univ Estado Rio De Janeiro, Inst Biol, Dept Physiol, BR-20551030 Rio De Janeiro, RJ, Brazil

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2020年 / 45卷 / 11期

关键词：

acai; fluoxetine; anxiety; maternal separation; oxidative stress; hypothalamic-pituitary-adrenal axis; neurogenesis; EARLY-LIFE STRESS; OXIDATIVE STRESS; NEUROTROPHIC FACTOR; TEA POLYPHENOLS; GREEN TEA; FLUOXETINE; DISORDERS; ANXIETY; DEPRESSION; ACTIVATION;

D O I：

10.1139/apnm-2020-0099

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Many studies suggest a protective role of phenolic compounds in mood disorders. We aimed to assess the effect of Euterpe oleracea (acai) seed extract (ASE) on anxiety induced by periodic maternal separation (PMS) in adult male rats. Animals were divided into 6 groups: control, ASE, fluoxetine (FLU), PMS, PMS+ASE, and PMS+FLU. For PMS, pups were separated daily from the dam for 3 h between postnatal day (PN) 2 and PN21. ASE (200 mg.kg(-1).day(-1)) and FLU (10 mg.kg(-1).day(-1)) were administered by gavage for 34 days after stress induction, starting at PN76. At PN106 and PN108, the rats were submitted to open field (OF) and forced swim tests, respectively. At PN110, the rats were sacrificed by decapitation. ASE increased time spent in the center area in the OF test, glucocorticoid receptors in the hypothalamus, tropomyosin receptor kinase B (TRKB) levels in the hippocampus, and nitrite levels and antioxidant activity in the brain stem (PMS+ASE group compared with PMS group). ASE also reduced plasma corticotropin-releasing hormone levels, adrenal norepinephrine levels, and oxidative damage in the brain stem in adult male offspring submitted to PMS. In conclusion, ASE treatment has an anti-anxiety effect in rats submitted to PMS by reducing hypothalamic-pituitary-adrenal axis reactivity and increasing the nitric oxide (NO)-brain-derived neurotrophic factor (BDNF)-TRKB pathway and antioxidant defense in the central nervous system. Novelty ASE has anti-anxiety and antioxidant effects in early-life stress. ASE reduces hypothalamic-pituitary-adrenal axis reactivity. The anxiolytic effect of ASE may involve activation of the NO-BDNF-TRKB pathway in the central nervous system.

引用

页码：1277 / 1286

页数：10

共 74 条

[21] Euterpe oleracea Mart.-Derived Polyphenols Protect Mice from Diet-Induced Obesity and Fatty Liver by Regulating Hepatic Lipogenesis and Cholesterol Excretion [J].

de Oliveira, Paola Raquel B. ;

da Costa, Cristiane A. ;

de Bem, Graziele F. ;

Cordeiro, Viviane S. C. ;

Santos, Izabelle B. ;

de Carvalho, Lenize C. R. M. ;

da Conceicao, Ellen Paula S. ;

Lisboa, Patrcia Cristina ;

Ognibene, Dayane T. ;

Sousa, Pergentino Jose C. ;

Martins, Gabriel R. ;

da Silva, Antonio Jorge R. ;

de Moura, Roberto S. ;

Resende, Angela C. .

PLOS ONE, 2015, 10 (12)

[22] Stress, glucocorticoids and memory: implications for treating fear-related disorders [J].

de Quervain, Dominique ;

Schwabe, Lars ;

Roozendaal, Benno .

NATURE REVIEWS NEUROSCIENCE, 2017, 18 (01) :7-19

[23]

DRAPER HH, 1990, METHOD ENZYMOL, V186, P421

[24] Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes [J].

Du, Yu ;

Guo, Huaifang ;

Lou, Hongxiang .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (05) :1695-1701

[25] Some Current Insights into Oxidative Stress [J].

Durackova, Z. .

PHYSIOLOGICAL RESEARCH, 2010, 59 (04) :459-469

[26] Flavonoid-rich fraction of the Monodora tenuifolia seed extract attenuates behavioural alterations and oxidative damage in forced-swim stressed rats [J].

Ekeanyanwu, Raphael Chukwuma ;

Njoku, Obioma Uzoma .

CHINESE JOURNAL OF NATURAL MEDICINES, 2015, 13 (03) :183-191

[27] SEVERITY OF ANXIETY AND WORK-RELATED OUTCOMES OF PATIENTS WITH ANXIETY DISORDERS [J].

Erickson, Steven R. ;

Guthrie, Sally ;

VanEtten-Lee, Michelle ;

Himle, Joseph ;

Hoffman, Jody ;

Santos, Susana F. ;

Janeck, Amy S. ;

Zivin, Kara ;

Abelson, James L. .

DEPRESSION AND ANXIETY, 2009, 26 (12) :1165-1171

[28] Chemo-mapping and biochemical-modulatory and antioxidant/prooxidant effect of Galium verum extract during acute restraint and dark stress in female rats [J].

Farcas, Anca D. ;

Mot, Augustin C. ;

Zagrean-Tuza, Cezara ;

Toma, Vlad ;

Cimpoiu, Claudia ;

Hosu, Anamaria ;

Parvu, Marcel ;

Roman, Ioana ;

Silaghi-Dumitrescu, Radu .

PLOS ONE, 2018, 13 (07)

[29] Early ethanol exposure in mice increases laterality of rotational side preference in the free-swimming test [J].

Filgueiras, Claudio C. ;

Ribeiro-Carvalho, Anderson ;

Nunes, Fernanda ;

Abreu-Villaca, Yael ;

Manhaes, Alex C. .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2009, 93 (02) :148-154

[30]

FLOHE L, 1984, METHOD ENZYMOL, V105, P114

← 1 2 3 4 5 6 7 8 →