Dual Redox and Thermoresponsive Double Hydrophilic Block Copolymers with Tunable Thermoresponsive Properties and Self-Assembly Behavior

被引:26
作者
Chan, Nicky [1 ]
An, So Young [1 ]
Yee, Nathan [1 ]
Oh, Jung Kwon [1 ]
机构
[1] Concordia Univ, Dept Chem & Biochem, Montreal, PQ H3G 1M8, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
atom transfer radical polymerization; double hydrophilic block copolymer; LCST; self-assembly; thiol-disulfide degradation; TRANSFER RADICAL POLYMERIZATION; POLY N-ISOPROPYLACRYLAMIDE; THERMOSENSITIVE POLYMERS; BIOLOGICAL APPLICATIONS; INTRACELLULAR DRUG; CLICK CHEMISTRY; MICELLES; LCST; POLY(N-ISOPROPYLACRYLAMIDE); DELIVERY;
D O I
10.1002/marc.201300852
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The synthesis, tunable thermoresponsive properties, and self-assembly of dual redox and thermoresponsive double hydrophilic block copolymers having pendant disulfide linkages (DHBCss) are reported. Well-defined DHBCss composed of a hydrophilic poly(ethylene oxide) block and a dual thermo- and reduction-responsive random copolymer block containing pendant disulfide linkages are synthesized by atom transfer radical polymerization. Their lower critical solution temperature (LCST) transitions are adjusted through modulating pendant hydrophobic-hydrophilic balance with disulfide-thiol-sulfide chemistry. Further, these DHBCss derivatives are converted to disulfide-crosslinked nanogels at temperatures above LCST through temperature-driven self-assembly and in situ disulfide crosslinking. They exhibit enhanced colloidal stability and further reduction-responsive degradability, thus demonstrating versatility of dual thermo- and reduction-responsive smart materials. <boxed-text content-type="graphic" position="anchor"> <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="urn:x-wiley:10221336:media:marc201300852:marc201300852-abs-0001">image</graphic
引用
收藏
页码:752 / 757
页数:6
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