Modulation of Ca2+ channels by activation of adenosine A(1) receptors in rat striatal glutamatergic nerve terminals

被引：23

作者：

Ambrosio, AF

Malva, JO

Carvalho, AP

Carvalho, CM

机构：

[1] UNIV COIMBRA,DEPT ZOOL,CTR NEUROSCI,COIMBRA,PORTUGAL

[2] UNIV COIMBRA,FAC MED,COIMBRA,PORTUGAL

[3] UNIV MINHO,DEPT BIOL,BRAGA,PORTUGAL

来源：

NEUROSCIENCE LETTERS | 1996年 / 220卷 / 03期

关键词：

adenosine A(1) receptor; striatal synaptosomes; Ca2+ channels; Ca2+](i); glutamate release;

D O I：

10.1016/S0304-3940(96)13252-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We determined that activation of adenosine A(1) receptors in striatal synaptosomes with 100 nM N-6-cyclopentyladenosine (CPA) inhibited both the release of endogenous glutamate and the increase of intracellular free Ca2+ concentration ([Ca2+](i)), due to 4-aminopyridine (4-AP) stimulation, by 28 and 19%, respectively. Furthermore, CPA enhanced the inhibition of endogenous glutamate release due to omega-conotoxin GVIA (omega-Cgtx GVIA), omega-Cgtx MVIIC or omega-Cgtx GVIA plus omega-Cgtx MVIIC. Similar effects were observed in the [Ca2+](i) signal. The inhibitory effects of CPA and omega-Cgtx GVIA were additive, but the effects of CPA and omega-Cgtx MVIIC were only partially additive. These results suggest that P/Q-type Ca2+ channels and other type(s) of Ca2+ channel(s), coupled to glutamate release, are inhibited subsequently to activation of adenosine A(1) receptors. (C) 1996 Elsevier Science Ireland Ltd.

引用

页码：163 / 166

页数：4

共 21 条

[1]

AIUCHI T, 1989, CHEM PHARM BULL, V37, P3333

[2]

BARRIE AP, 1993, J NEUROCHEM, V60, P1081

[3] Voltage-sensitive Ca2+ channels in rat striatal synaptosomes: Role on the [Ca2+](i) responses to membrane depolarization [J].