Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses

被引：156

作者：

Lande, Roberto ^{[1
]}

Gilliet, Michel ^{[1
,2
,3
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[2] Univ Texas Houston, MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA

[3] Univ Texas Houston, MD Anderson Canc Ctr, Dept Dermatol, Houston, TX 77030 USA

来源：

YEAR IN IMMUNOLOGY 2 | 2010年 / 1183卷

关键词：

plasmacytoid dendritic cells; immunity; human diseases; pathogenesis; T cells; INTERFERON-PRODUCING CELLS; TOLL-LIKE RECEPTORS; INFLAMED LYMPH-NODES; SINGLE-STRANDED RNA; CD8(+) T-CELLS; I INTERFERON; IFN-ALPHA; PREDENDRITIC CELLS; ANTIVIRAL RESPONSES; INFLUENZA-VIRUS;

D O I：

10.1111/j.1749-6632.2009.05152.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of type I IFNs, pDCs initiate protective immunity by activating classical DCs, T cells, natural killer cells, and B cells. Upon activation, pDCs also differentiate into mature DCs and may contribute to the contraction of T-cell responses. In this review, we describe how pDCs are key players in the initiation and regulation of immune responses and discuss their emerging role in the pathogenesis of human diseases.

引用

页码：89 / 103

页数：15

共 167 条

[1] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2] Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment [J].

Albanesi, Cristina ;

Scarponi, Claudia ;

Pallotta, Sabatino ;

Daniele, Roberta ;

Bosisio, Daniela ;

Madonna, Stefania ;

Fortugno, Paola ;

Gonzalvo-Feo, Safiye ;

Franssen, Jean-Denis ;

Parmentier, Marc ;

De Pita, Ornella ;

Girolomoni, Giampiero ;

Sozzani, Silvano .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (01) :249-258

[3] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[4] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[5] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[6] Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus [J].

Barrat, FJ ;

Meeker, T ;

Gregorio, J ;

Chan, JH ;

Uematsu, S ;

Akira, S ;

Chang, B ;

Duramad, O ;

Coffman, RL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1131-1139

[7] Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA [J].

Barton, GM ;

Kagan, JC ;

Medzhitov, R .

NATURE IMMUNOLOGY, 2006, 7 (01) :49-56

[8] Interferon and granulopoiesis signatures in systemic lupus erythematosus blood [J].

Bennett, L ;

Palucka, AK ;

Arce, E ;

Cantrell, V ;

Borvak, J ;

Banchereau, J ;

Pascual, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :711-723

[9] Mucosal CD8α+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties [J].

Bilsborough, J ;

George, TC ;

Norment, A ;

Viney, JL .

IMMUNOLOGY, 2003, 108 (04) :481-492

[10] Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice [J].

Björck, P .

BLOOD, 2001, 98 (13) :3520-3526

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