Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients

被引：29

作者：

Kishi, Taro ^{[1
]}

Tsunoka, Tomoko ^{[1
]}

Ikeda, Masashi ^{[1
,2
]}

Kitajima, Tsuyoshi ^{[1
]}

Kawashima, Kunihiro ^{[1
]}

Okochi, Tomo ^{[1
]}

Okumura, Takenori ^{[1
]}

Yamanouchi, Yoshio ^{[1
]}

Kinoshita, Yoko ^{[1
]}

Ujike, Hiroshi ^{[3
,4
]}

Inada, Toshiya ^{[3
,5
]}

Yamada, Mitsuhiko ^{[3
,6
]}

Uchimura, Naohisa ^{[3
,7
]}

Sora, Ichiro ^{[3
,8
]}

Iyo, Masaomi ^{[3
,9
]}

Ozaki, Norio ^{[3
,10
]}

Iwata, Nakao ^{[1
,3
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Psychiat, Aichi 4701192, Japan

[2] Cardiff Univ, Sch Med, Dept Psychol Med, Cardiff CF14 4XN, S Glam, Wales

[3] Japanese Genet Initiat Drug Abuse, Tokyo, Japan

[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008558, Japan

[5] Seiwa Hosp, Inst Neuropsychiat, Dept Psychiat, Tokyo 1620851, Japan

[6] Natl Ctr Neurol & Psychiat, NIMH, Ichikawa 2720827, Japan

[7] Kurume Univ, Sch Med, Dept Neuropsychiat, Kurume, Fukuoka 8300011, Japan

[8] Tohoku Univ, Grad Sch Med, Dept Neurosci, Dept Psychobiol, Sendai, Miyagi 9808576, Japan

[9] Chiba Univ, Grad Sch Med, Dept Psychiat, Chiba 2608677, Japan

[10] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi 4668850, Japan

来源：

NEUROPHARMACOLOGY | 2010年 / 58卷 / 02期

关键词：

Serotonin 1A receptor gene (HTR1A); Functional SNP; Tagging SNP; Methamphetamine-induced psychosis; 5-HT1A RECEPTORS; TREATMENT RESPONSE; MOOD DISORDERS; ANTIDEPRESSANT RESPONSE; C(-1019)G POLYMORPHISM; CHRONIC-SCHIZOPHRENIA; PREFRONTAL CORTEX; MAJOR DEPRESSION; SYMPTOM RESPONSE; HUMAN BRAIN;

D O I：

10.1016/j.neuropharm.2009.09.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Several investigations have reported associations the serotonin 1A (5-HT1A) receptor to schizophrenia and psychotic disorders, making 5-HT1A receptor gene (HTR1A) an adequate candidate gene for the pathophysiology of schizophrenia and methamphetamine (METH)-induced psychosis. Huang and colleagues reported that rs6295 in HTR1A was associated with schizophrenia. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. It may indicate that METH-induced psychosis and schizophrenia have common susceptibility genes. In support of this hypothesis, we reported that the V-act murine thymoma viral oncogene homologue I (AKT1) gene was associated with METH-induced psychosis and schizophrenia in the Japanese population. Furthermore, we conducted an analysis of the association of HTR1A with METH-induced psychosis. Method: Using one functional SNP (rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results: Rs878567 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this significance remained after Bonferroni correction. In addition, we detected an association between rs6295 and rs878567 in HTR1A and METH-induced psychosis patients in the haplotype-wise analysis. Although we detected an association between rs6295 and METH-induced psychosis patients, this significance disappeared after Bonferroni correction. Conclusion: HTR1A may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population. However, because we did not perform a mutation scan of HTR1A, a replication study using a larger sample may be required for conclusive results. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：452 / 456

页数：5

共 53 条

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