LincRNa-p21: function and mechanism in cancer

被引：76

作者：

Chen, Shaoyun ^{[1
]}

Liang, Hairong ^{[1
]}

Yang, Hui ^{[1
]}

Zhou, Kairu ^{[1
]}

Xu, Longmei ^{[1
]}

Liu, Jiaxian ^{[1
]}

Lai, Bei ^{[1
]}

Song, Li ^{[1
]}

Luo, Hao ^{[1
]}

Peng, Jianming ^{[2
]}

Liu, Zhidong ^{[2
]}

Xiao, Yongmei ^{[3
]}

Chen, Wen ^{[3
]}

Tang, Huanwen ^{[1
]}

机构：

[1] Guangdong Med Univ, Sch Publ Hlth, Dongguan Key Lab Environm Med, Dept Environm & Occupat Hlth, Dongguan 523808, Peoples R China

[2] Huizhou Prevent & Treatment Ctr Occupat Dis, Huizhou 516000, Peoples R China

[3] Sun Yat Sen Univ, Dept Toxicol, Sch Publ Hlth, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Guangzhou 510080, Guangdong, Peoples R China

来源：

MEDICAL ONCOLOGY | 2017年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Long noncoding RNAs; LincRNa; p21; Genes expression; Cancer; INTERGENIC NONCODING RNA-P21; PLURIPOTENT STEM-CELLS; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; PROSTATE-CANCER; SOMATIC-CELLS; IN-VITRO; ANGIOGENESIS; P53; EXPRESSION;

D O I：

10.1007/s12032-017-0959-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In view of the rapid development of gene chips and high-throughput sequencing technology, noncoding RNAs (ncRNas) form a high percentage of the mammalian genome. Two major subgroups of ncRNAs that have been identified are the long ncRNAs (lncRNas) and the microRNAs. A number of studies in the past few years have showed crucial functions for lncRNas in cancer. LincRNa-p21 as a p53-dependent transcriptional target gene and a potential diagnostic marker is involved in proliferation, cell cycle, metabolism and reprogramming. In addition, more researches revealed that lincRNa-p21 is associated with cancer progression and contributed to the treatment and prognosis of cancer. In this review, we briefly summarize the function and molecular mechanisms of lincRNa-p21 in cancer and its regulation for the genes expression.

引用

页数：8

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