Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol-Induced Myocardial Oxidative Stress in Rats

被引：2
|
作者：
Kariyappa, Anupama Sindhaghatta [1 ]
Ramachandregowda, Sowbhagya [2 ]
Anand, Santosh [2 ]
Dundaiah, Bhagyalakshmi [1 ]
Gopinath, Mamatha Madhugiri [1 ]
Tekupalli, Ravikiran [1 ]
机构：
[1] Bangalore Univ, Dept Biotechnol, Jnanabharathi Campus, Bengaluru 560056, Karnataka, India
[2] Ramaiah Coll Arts Sci & Commerce, Bengaluru, Karnataka, India
来源：
PHARMACOGNOSY MAGAZINE | 2019年 / 15卷 / 64期
关键词：
Decalepis hamiltonii; isoproterenol; myocardial infarction; oxidative stress; serum lipid profile; ANTIOXIDANT STATUS; AQUEOUS EXTRACT; INDUCED CARDIOTOXICITY; ELLAGIC ACID; IN-VIVO; INFARCTION; ISCHEMIA; INJURY; TISSUE; ASSAYS;
D O I：
10.4103/pm.pm_642_18
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: Decalepis hamiltonii (Dh), a climbing shrub belonging to the family Apocynaceae, is consumed for its health-promoting properties. Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region-specific responses against isoproterenol (ISO)-induced myocardial injury in male Wistar rats. Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4-hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days. Results: ISO-treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO-administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO-induced myocardial infarction (MI). Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO-induced MI in rats.
引用
收藏
页码：320 / 327
页数：8
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